Cells of which genome is modified
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsNaoko Yamane, Mitsuo Satoh, Katsuhiro Mori, Kazuya Yamano
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Abstract
A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain than its parent cell, and a process for producing an antibody composition using the cell.
Claims43
A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain than its parent cell.
An antibody composition comprising an antibody molecule having an glycoside-linked sugar chain in the Fc region, which has a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in the antibody composition.
Dependencies are inferred from the claim text.