Modulation of DR1-associated protein 1 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsMing-Yi Chiang, Kenneth W. Dobie
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Abstract
Compounds, compositions and methods are provided for modulating the expression of DR1-associated protein 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DR1-associated protein 1. Methods of using these compounds for modulation of DR1-associated protein 1 expression and for diagnosis and treatment of disease associated with expression of DR1-associated protein 1 are provided.
Claims24
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding DR1-associated protein 1, wherein said compound specifically hybridizes with said nucleic acid molecule encoding DR1-associated protein 1 (SEQ ID NO:
- 4) and inhibits the expression of DR1-associated protein 1.
A method of screening for a modulator of DR1-associated protein 1, the method comprising the steps of:
- a. contacting a preferred target segment of a nucleic acid molecule encoding DR1-associated protein 1 with one or more candidate modulators of DR1-associated protein 1, and
- b. identifying one or more modulators of DR1-associated protein 1 expression which modulate the expression of DR1-associated protein 1.
A diagnostic method for identifying a disease state comprising identifying the presence of DR1-associated protein 1 in a sample using at least one of the primers comprising SEQ ID NOs 5 or 6, or the probe comprising SEQ ID NO 7.
Dependencies are inferred from the claim text.