Modulation of CD1D expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Susan M. Freier
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Abstract
Compounds, compositions and methods are provided for modulating the expression of CD1D. The compositions comprise oligonucleotides, targeted to nucleic acid encoding CD1D. Methods of using these compounds for modulation of CD1D expression and for diagnosis and treatment of disease associated with expression of CD1D are provided.
Claims24
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding CD1D, wherein said compound specifically hybridizes with said nucleic acid molecule encoding CD1D (SEQ ID NO:4) and inhibits the expression of CD1D.
A method of screening for a modulator of CD1D, the method comprising the steps of:
- a. contacting a preferred target segment of a nucleic acid molecule encoding CD1D with one or more candidate modulators of CD1D, and
- b. identifying one or more modulators of CD1D expression which modulate the expression of CD1D.
A diagnostic method for identifying a disease state comprising identifying the presence of CD1D in a sample using at least one of the primers comprising SEQ ID NOs:5 or 6, or the probe comprising SEQ ID NO:7.
Dependencies are inferred from the claim text.