Modulation of ABCC2 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorKenneth W. Dobie
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Abstract
Compounds, compositions and methods are provided for modulating the expression of ABCC2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ABCC2. Methods of using these compounds for modulation of ABCC2 expression and for diagnosis and treatment of disease associated with expression of ABCC2 are provided.
Claims24
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding ABCC2, wherein said compound specifically hybridizes with said nucleic acid molecule encoding ABCC2 (SEQ ID NO:
- 4) and inhibits the expression of ABCC2.
A method of screening for a modulator of ABCC2, the method comprising the steps of:
- a. contacting a preferred target segment of a nucleic acid molecule encoding ABCC2 with one or more candidate modulators of ABCC2, and
- b. identifying one or more modulators of ABCC2 expression which modulate the expression of ABCC2.
A diagnostic method for identifying a disease state comprising identifying the presence of ABCC2 in a sample using at least one of the primers comprising SEQ ID NOs 5 or 6, or the probe comprising SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.