Immunotherapeutic methods and compositions
OwnerJames Dobbieinventor
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Abstract
This invention relates to methods and compositions introducing chemical entities into antigen presenting cells. The resulting presentation of said antigens on the surface of the antigen presenting cells gives an effect on the immune system. The invention also relates to the resulting modified antigen presenting cells and pharmaceutical compositions containing these cells. The invention discloses new understandings in adjuvancy and adjuvant preparations, including a series of related peptides and phospholipid vesicles incorporating said peptides.
Claims23
A phospholipid vesicle for producing an immune response, the phospholipid vesicle having an exogenous antigen or a polynucleic acid coding for an antigen therein, the phospholipid vesicle being adapted to be phagocytosed by antigen presenting cells and the phospholipid composition being less than 20% cholestrol.
A phospholipid vesicle as claimed in any of the previous claims, wherein the phospholipid composition is at least 15% sphingomyelin.
A phospholipid vesicle as described in any of the previous claims, wherein in the phospholipid composition of the phospholipid vesicle comprises phosphotidylcholine 44% to 60%, sphingomyelin 50% to 25%, phosphotidylethanolymine 6% to 10%, phosphotidylserine 2% to 6%, phosphotidylinositol 2% to 4% and cholesterol 4% to 12%. Wherein the figures are percentage by weight.
A phospholipid vesicle as described in any of the previous claims, wherein the phospholipid composition comprises phosphotidylcholine 54%, sphingomyelin 19%, phosphotidylethanolymine 8%, phosphotidylserine 4%, phosphotidylinositol 3% and cholesterol 10% Wherein the figures are percentage by weight.
A phospholipid vesicle as claimed in any of the previous claims, wherein the phospholipid composition includes lysolecithin.
A phospholipid vesicle as claimed in any of the previous claims, wherein the vesicle is a lamellar body isolated from the mammalian body.
A phospholipid vesicle as in any of the previous claims for use as a vaccination agent.
Modified antigen presenting cells for inducing a cellular immune response comprising antigen presenting cells isolated from a mammalian body, modified by take-up of phospholipid vesicles according to any of the previous claims.
Dependencies are inferred from the claim text.