Cell proliferation factor Fwa267
AssigneeCardiovascular Institute of Chinese Academy of Medical Sciences
InventorsRutai Hui, Jingzhou Chen, Baohua Liu, Yuqing Liu
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Abstract
The application disclosed a cell proliferation factor-Fwa267 polypeptide and the polynucleotide encoding the polypeptide and a process for producing the polypeptide by recombinant method, the antibody and antagonist against the polypeptide and a composition comprising Fwa267 polypeptide and its usage in the treatment of angiocardiopathy and cancer are also disclosed. The application further disclosed a diagnostic method by detecting the mutation in the nucleic acid sequence encoding Fwa 267 or the amount of Fwa267 in the sample or the changes of autoantibody of Fwa267 gene product. The cell proliferation factor of the present application is of human resource.
Claims19
An isolated polynucleotide selected from the group consisting of:
- (a) a polynucleotide having a sequence encoded as the polypeptide of SEQ ID NO:2;
- (b) a polynucleotide that is a variant of naturally occurring (a);
- and
- (c) a polynucleotide able to hybridize with (a) and having at least 85% homology with (a).
A polypeptide selected from the group consisting of:
- (a) a polypeptide having an inferred amino acid sequence set forth in SEQ ID NO:2;
- (b) a polypeptide which is an active fragment, analog or derivative of (a);
- and
- (c) a polypeptide having at least 85% homology with the amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.