Methods for modulating cell survival
OwnerMichael Hayden, Abigail Hackam +2inventors
InventorsMichael Hayden, Abigail Hackam, Blair R. Leavitt, Edmond Chan
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Abstract
In general, the invention provides methods, reagents, and uses for modulating cell survival. In various alternative aspects, the invention provides methods of modulating cell survival by administering a huntingtin protein or a biologically-active fragment or variant thereof, or methods of treatment or prophylaxis of a cell degenerative disease or a cell proliferative disease by administering a huntingtin protein or a biologically-active fragment or variant thereof. In various alternative aspects, the invention provides diagnostic assays or methods of assaying test compounds using a huntingtin protein or a biologically-active fragment or variant thereof.
Claims36
A method of modulating cell survival in a subject in need thereof, said method comprising administering an effective amount of a huntingtin protein or a biologically-active fragment or variant thereof.
A method of treatment or prophylaxis of a cell degenerative disease, said method comprising administering a huntingtin protein or a biologically-active fragment or variant thereof, to a subject in need thereof.
A method of treatment or prophylaxis of a cell proliferation disease, said method comprising administering a huntingtin protein or a biologically-active fragment or variant thereof, to a subject in need thereof.
A method of assaying a test compound, said method comprising:
- (a) providing a system comprising a huntingtin protein or biologically-active fragment thereof,
- (b) contacting said system with said test compound, and
- (c) determining whether said test compound modulates the phosphorylation of said huntingtin protein or fragment thereof.
A method of assaying a test compound, said method comprising:
- (a) providing a system comprising a huntingtin protein or biologically-active fragment thereof,
- (b) contacting said system with said test compound, and
- (c) determining whether said test compound modulates a function of said huntingtin protein or fragment thereof, wherein said function is selected from the group consisting of apoptosis inhibition, aggregation inhibition, and cell proliferation.
A method of ameliorating the cytotoxic effects of a therapeutic compound, said method comprising administering a huntingtin protein or a biologically-active fragment or variant thereof with said therapeutic compound.
A method for diagnosing cell proliferation, said method comprising determining the level of a huntingtin protein or nucleic acid molecule in a test sample and in a control sample, wherein said test sample is positive for cell proliferation if said level is higher in said test sample than in said control sample.
Dependencies are inferred from the claim text.