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US 2004/0110674 A1Published application
Nucleic acid and corresponding protein entitled 205p1b5 useful in treatment and detection of cancer
AssigneeAgensys, Inc.
InventorsPia M. Challita-Eid, Arthur B. Raitano, Mary Faris, Rene S. Hubert, Aya Jakobovits
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Abstract
A novel gene (designated 205P1B5) and its encoded protein are described. While 205P1B5 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostrate cancer. Consequently, 205P1B5 provides a diagnostic, prognostic, prophlactic and/or therapeutic target for cancer. The 205P1B5 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
Claims51
A composition comprising:
- a substance that a) modulates the status of a protein of FIG. 2 (SEQ ID NOS:
- 3, 5, 7, 9, 11, 13, 15, 17, 19 and 21), or b) a molecule that is modulated by a protein of FIG. 2, whereby the status of a cell that expresses a protein of FIG. 2 is modulated.
A method of generating a mammalian immune response directed to a protein of FIG. 2, the method comprising:
- exposing cells of the mammal's immune system to a portion of
- a) a 205P1B5-related protein and/or
- b) a nucleotide sequence that encodes said protein,
- whereby an immune response is generated to said protein.
1 more element
Dependencies are inferred from the claim text.