Use of soluble forms of CD83 and nucleic acids encoding them for the treatment or prevention of diseases
AssigneeArgos Therapeutics, Inc.
InventorsAlexander Steinkasserer, Matthias Lechmann, Elisabeth Zinser
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Abstract
The present invention provides for the use of soluble forms of CD83 and nucleic acids encoding them for the treatment of diseases caused by the dysfunction or undesired function of a cellular immune response involving T cells. The invention moreover provides soluble CD83 molecules specifically suited for said purpose, antibodies against said specific soluble CD83 proteins and assay methods and kits comprising said antibodies.
Claims28
A method of treatment or prevention of a disease or medical condition caused by the dysfunction or undesired function of a cellular immune response involving T cells, which comprises administering to a subject in need of such treatment an effective amount of a soluble form of one or more members of the CD83 family of proteins (soluble CD83 protein).
A method of treatment or prevention of a disease or medical condition caused by the dysfunction or undesired function of a cellular immune response involving T cells, which comprises administering at least one nucleic acid or vector having a DNA fragment encoding a soluble form of a member of the CD83 family of proteins (soluble CD83 protein).
A soluble form of a member of the CD83 family of proteins (soluble CD83 protein) comprising amino acids 20 to 144 of SEQ ID NO:2 or a fragment or derivative thereof.
Dependencies are inferred from the claim text.