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OwnerDaniel Kahne, Suzanne Walker +1inventors
InventorsDaniel Kahne, Suzanne Walker, Domingos J. Silva
Estimating the term…
Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A1-A2-A3-A4-A5-A6-A7 wherein each of the groups A2 to A7 is a modified or unmodified α-amino acid residue, A1 is optional and, when present, is an organic group other than N-substituted leucine, and at least one of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent. Methods of making these compounds, compositions including these compounds, and methods of using the compounds to treat infections in a host are also disclosed.
A compound having the formula A1-A2-A3-A4-A5-A6-A7 wherein each of the groups A2 to A7 comprises a modified or unmodified α-amino acid residue, A1 is optional and, when present, comprises an organic group other than N-substituted leucine, and at least one of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent.
A method for making a compound of the formula A1-A2-A3-A4-A5-A6-A7 wherein each of the groups A2 to A7 comprises a modified or unmodified a-amino acid residue, A1 comprises an organic group other than N-substituted leucine, and at least one of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent, said method comprising
A method for making a glycopeptide antibiotic having the formula A1-A2-A3-A4-A5-A6-A7 wherein A2-A3-A4-A5-A6-A7 is as found in vancomycin and AI comprises an organic group other than N-substituted leucine, said method comprising
A method for making a glycopeptide antibiotic having the formula A1-A2-A3-A4-A5-A6-A7 wherein A2-A3-A4-A5-A6-A7 is as found in vancomycin and AI comprises an organic group other than N-substituted leucine, said method comprising
A method for removing an N-terminal amino acid residue from an oligopeptide or polypeptide comprising reacting an oligopeptide or a polypeptide with phenylisothiocyanate in a pyridine-water-triethylamine solvent medium.
Dependencies are inferred from the claim text.