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OwnerMadhav V. Dhodapkar, RalphM M Stein +1inventors
InventorsMadhav V. Dhodapkar, RalphM M Stein, Nina Bhardwaj
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This invention provides methods for silencing a pre-existing immune response in a mammal, as for example, in the setting of autoimmune diseases. The method comprises administering to a mammal immature dendritic cells which have been contacted in vitro with an antigen, or to target the antigen to immature dendritic cells in vivo, in order to silence and/or suppress a pre-existing CD8+T cell immune response and induce IL-10 producing CD8+T cells in said mammal. This invention further relates to methods for propagating immature dendritic cells, for maintaining immaturity by modification ex vivo, and uses thereof, including generation of regulatory T cells for passive immunotherapy. The present invention also relates to compositions and kits comprising immature dendritic cells and antigens.
A method of silencing or suppressing a pre-existing immune response to an antigen in a mammal, wherein said immune response is characterized by the presence of CD8+T cells which are specific for said antigen, and wherein said method comprises administering to said mammal a sufficient amount of immature dendritic cells which have been contacted with said antigen to suppress or silence said immune response.
A method for silencing or suppressing the function of pre-existing CD8+T cells which are specific for an antigen in a mammal comprising:
A kit for inhibiting the function of pre-existing antigen specific T cells, which kit comprises immature dendritic cells which have been contacted with said antigen.
A kit for inhibiting the function of pre-existing antigen specific T cells, which kit comprises immature dendritic cells and said antigen.
A method for generating antigen specific regulatory CD8+T cells in vitro for adoptive immunotherapy, wherein said method comprises contacting T cells in vitro with immature dendritic cells containing an antigen for a time sufficient to generate antigen specific regulatory CD8+T cells, and administering said regulatory CD8+T cells to a mammal in an amount sufficient to suppress an immune response.
Dependencies are inferred from the claim text.