Medical devices for delivery of therapeutic agents
AssigneeBoston Scientific Scimed, Inc.
InventorsMaria Palasis, Wendy Naimark, Robert E. Richard
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Abstract
The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices.
Claims68
A medical device, at least a portion of which is insertable or implantable into the body of a patient, said medical device comprising:
- a plasmid DNA layer comprising plasmid DNA;
- and
- a polymeric covering layer disposed over said plasmid DNA layer.
A medical device, at least a portion of which is insertable or implantable into the body of a patient, said medical device comprising:
- a therapeutic agent containing layer comprising a high-molecular-weight therapeutic agent;
- and
- a polymeric covering layer disposed over said therapeutic agent containing layer, said polymeric covering layer comprising one or more polymers selected from (a) a block copolymer comprising at least two polymeric blocks A and B, wherein A is a polyolefin block and wherein B is a vinyl aromatic block, (b) a polymer or copolymer of lactic acid, (c) a polymer or copolymer of glycolic acid, and (d) a tyrosine-based polymer or copolymer.
A medical device, at least a portion of which is insertable or implantable into the body of a patient, said medical device comprising:
- a polymeric layer comprising (a) a block copolymer comprising at least two polymeric blocks A and B and a removable component, wherein A is a polyolefin block and wherein B is a vinyl aromatic block or (b) a tyrosine-based polymer or copolymer and a removable component;
- and
- a high-molecular-weight therapeutic agent disposed below or within said polymeric layer.
A medical device, at least a portion of which is insertable or implantable into the body of a patient, said medical device comprising:
- a polymeric layer comprising a polymer and a plasticizer;
- and
- a high-molecular-weight polynucleotide therapeutic agent disposed below or within said polymeric layer.
A medical device comprising a multi-layer coating which covers at least a portion of the medical device, said multi-layer coating comprising:
- (a) one or more therapeutic agent containing layers comprising a therapeutic agent and
- (b) one or more polymeric layers comprising a polymer, said one or more polymeric layers having a composition gradient in a direction normal to the surface of the coating.
Dependencies are inferred from the claim text.