Process for the preparation of cyclohexanol derivatives
OwnerLan Zhiyin, Shi Kaiyun +2inventors
InventorsLan Zhiyin, Shi Kaiyun, Mo Qizhuang, Li Yulin
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Abstract
A reaction of a para-substituted aryl composition with cyclohexanone is facilitated by a metal hydride, such as NaH, KH, LiH, MgH2, CaH2, AlH3, and/or LiAlH4 to make first intermediates useful in producing a drug commonly known as Venlafaxine. Alternatively, lithium diisopropylamide (diisopropylamino lithium) may be used in place of the metal hydride. The first intermediates may be further reacted to form second intermediates in a reduction that is facilitated by Rainey nickel or a metal hydride. These reaction processes may each occur in an organic solvent, which delivers highly pure reaction products in high yield.
Claims22
A process for preparing compounds of the formula
- 3
- wherein R1 denotes OH, or OCH3, and R2 denotes CN, CONH2, CONHCH3 or CON(CH3)2
- by reacting nitriles or amides of the formula
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- wherein R1 denotes OH, or OCH3, and R2 denotes CN, CONH2, CONHCH3 or CON(CH3)2,
- with cyclohexanone in the presence of a solvent and a base selected from the group consisting of NaH, KH, LiH, MgH2, CaH2, AlH3, LiAlH4 and combinations thereof.
A process for preparing compounds of the formula
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- wherein R1 denotes OH, or OCH3, and R2 denotes CN, CONH2, CONHCH3 or CON(CH3)2
- by reacting nitrites or amides of the formula
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- wherein R1 denotes OH, or OCH3, and R2 denotes CN, CONH2, CONHCH3 or CON(CH3)2,
- with diisopropylamino lithium solution in a solvent.
A process for preparing compounds of the formula
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- wherein R1 denotes OH, or OCH3, and R4 denotes CH2NH2, by reducing, in a solvent, a compound of the formula
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- wherein R1 denotes OH, or OCH3, and R2 denotes CN, by catalytic hydrogenation.
A process for preparing compounds of the formula
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- wherein R1 denotes OH, or OCH3, and R4 denotes CH2NH2, by reducing a compound of the formula
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- wherein R1 denotes OH, or OCH3, and R2 denotes CN, with a metal hydride in a solvent.
Dependencies are inferred from the claim text.