Preparation of aryl intermediates

A process of making a compound of the formula (A):

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• wherein the formula (A):
• P is a nitrogen protecting group chemically suitable for Grignard reagents,
• Y is defined herein below;
• the phenyl ring in (A) is optionally benzo-fused to form naphthyl wherein substituents Y or NH—P can be independently at any position on each of the one or two rings, where the phenyl is not benzo-fused then substitution can be para, meta or ortho;
• said method comprising, in a one pot reaction:
• reacting a compound of the formula (B) with 2 equivalents of R3MgLi, wherein and R is C1-5 alkyl, in an aprotic solvent at a temperature between −40° C. to 40° C.:
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• wherein X is bromine or iodine,
• subsequently adding an electrophile E as defined herein below, to produce a compound of the formula (A)
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• wherein E and Y have the following corresponding relationship in the table below:
• 2 E Y B(O—C1-5alkyl)3 —B(OH)2 R′HC═O —CHR′—OH R′2C(═O) —CR′2—OH R′X —R′ R′CO2R′ R′C(═O)— R′3SnX SnR′3 R′3SiX R′3Si R′2(OR′)SiX or SiR′2(OR′) (R′2SiO)3
• wherein R′ can be alkyl or aryl, X is halogen and for B(O—C1-5alkyl)3 the C1-5alkyl.