A compound represented by general formula (I), its stereoisomers, or its pharmaceutically acceptable salts
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- wherein
- X is O, S, SO, SO2, NR7 or CHR1;
- n is null or 1;
- k is null or 1;
- Z is O, S, and NR7;
- R1 at two positions are independently selected from hydrogen or a substituted or unsubstituted group selected from linear or branched (C1-C12)alkyl, (C2-C12)alkenyl, (C3-C7)cycloalkyl, (C5-C7)cycloalkenyl, bicycloalkyl, bicycloalkenyl, heterocycloalkyl, aryl, aryloxy, aralkyl, aralkoxy, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, wherein one or more heteroatoms are independently selected from O, N or S;
- R2, R3, R4 and R7 are independently selected from hydrogen, perhaloalkyl, —(CO)NR8R9, —(CO)R8, —(CO)OR8, —SO2R8, —SOR8, substituted or unsubstituted groups selected from linear or branched (C1-C12)alkyl, (C2-C12)alkenyl, (C3-C7)cycloalkyl, (C5-C7)cycloalkenyl, bicycloalkyl, tricycloalkyl amidino bicycloalkenyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, wherein one or more heteroatoms are independently selected from O, N or S;
- R5 and R6 are independently selected from by hydrogen or a substituted or unsubstituted group selected from linear or branched (C1-C12)alkyl, (C2-C12)alkenyl, (C3C7)cycloalkyl, (C5-C7)cycloalkenyl, bicycloalkyl, bicycloalkenyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, wherein one or more heteroatoms are independently selected from O, N or S;
- R8 and R9 are independently selected from hydrogen or a substituted and unsubstituted group selected from linear or branched (C1-C12)alkyl, alkoxyaryl, alkoxyalkyl, alkoxycycloalkyl, alkoxyaryl, perhaloalkyl, (C2-C12)alkenyl, (C3-C7) cycloalkyl, perhalocycloalkyl, haloheterocycloalkyl, cyanoheterocycloalkyl, perhaloheterocycloalkyl, (C5-C7) cycloalkenyl, bicycloalkyl, bicycloalkenyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, perhaloaryl, perhaloheteroaryl;
- wherein in the groups represented by R1, R2, R3, R4, R5, R6, R7, R8 and R9 when substituted, the substitutents are optionally and independently bridged by —(CO)—, —CH2(CO)—, —(CO)O—, —(CO)NH—, —CH2(CO)NH—, —NH—, —NR8—, —O, —S—, —(SO)—, —(SO2)—, —(SO2)NH—, —NHCH2(CO)NH—, —NH(SO2)—, —O(CO)— or —NH(CO)—;
- and are selected from halogen, hydroxy, nitro, cyano, amino, oxo, oxime, unsubstituted or substituted by R10 for the groups selected from linear or branched (C1-C8) alkyl, (C3-C7)cycloalkyl, tricycloalkyl, alkylcycloalkyl, alkoxyalkyl, perhaloalkyl, perhalocycloalkyl, aryl, aralkyl, alkylaryl, alkylheteroaryl, aralkoxylalkyl, perhaloaryl, alkylheterocycloalkyl, heterocycloalkyl, perhaloheterocyclyloalkyl, heteroaryl, heteroaralkyl, alkylaryl, perhaloheteroaryl, acyl, acyloxy, acylamino, alkylamino, arylamino, aralkoxy, alkoxyalkyl, alkylthio, thioalkyl, arylthio, thioaryl, carboxylic acid or its derivatives, or sulfonic acid or its derivatives wherein the groups/substituents present on same or adjacent atoms such as carbon or nitrogen;
- together optionally and independently may form a five or a six or a seven membered ring optionally containing one or more double bonds and optionally containing one or more heteroatoms selected from O, N or S;
- and wherein
- R10 is indepenideintly selected from naiogens, hydroxy, nitro, cyano, amino, alkoxy carbonyl alkyl, oxo or oxime, and pharmaceutically usable hydrates and salts thereof;
- with the proviso that,
- if k is null, then R4 and R6 together form an optionally six or seven membered ring, which optionally contains two to three heteroatoms independently selected from O, S and NR7 with R1 as hydrogen, and N1 is attached to hydrogen.