Process for producing 4-dimethyl amino pyridine (4-DMAP)
AssigneeM/s. Jubilant Organosys Limited
InventorsMahendra Kumar, Shailendra Kumar Singh, Ashutosh Agarwal
Life of this patent
Estimating the term…
Abstract
An improved process for producing 4-dimethyl amino pyridine is provided. The process comprises quaternizing pyridine with a suitable quaternizing agent in the presence of organic solvent, isolating the resulting salt and aminating the salt, N-[4-pyridyl] pyridinium chloride hydrochloride, with N,N-dimethyl formamide. The resultant reaction mass is hydrolysed in the presence of a base, extracted with an aromatic solvent and distilled under vacuum to produce 4-dimethyl amino pyridine.
Claims18
A process for producing 4-dimethyl amino pyridine comprising:
- quaternizing pyridine using a quaternizing agent in the presence of an organic solvent to form a salt;
- isolating the salt;
- aminating the salt employing an aminating agent to produce an organic mass;
- extracting the organic mass using an aromatic solvent;
- and
- distilling the extracted organic mass to produce 4-dimethyl amino pyridine.
A process for producing 4-dimethyl amino pyridine comprising:
- quaternizing pyridine using thionyl chloride in the presence of ethyl acetate to form N-[4-pyridyl] pyridinium chloride hydrochloride;
- isolating N-[4-pyridyl] pyridinium chloride hydrochloride in the presence of ethyl alcohol;
- aminating the N-[4-pyridyl] pyridinium chloride hydrochloride employing N,N-dimethyl formamide;
- hydrolyzing the resultant reaction mass in the presence of a base;
- extracting the reaction mass using an aromatic solvent;
- and
- distilling the extracted mass first atmospherically and then under vacuum to produce 4-dimethyl amino pyridine.
Dependencies are inferred from the claim text.