Peptide deformylase inhibitors

A compound according to formula (I):

• 7
• wherein:
• X is selected from the group consisting of —C(O)OC1-3alkyl, —OR1, —NR1R6, —C(O)NR1R6, or —C(O)R6;
• R1 is selected from the group consisting of hydrogen, C1-6alkyl, unsubstituted or substituted by one or more moieties selected from the group consisting of alcohol, ether, amine, amide, carboxylic acid, lactam, Ar, —C1-2alkylAr, C0-2alkylpiperidin-4-yl, substituted on nitrogen with R7, and C0-2alkylpyrrolidin-3-yl, substituted on nitrogen with R7 or C0-2 morpholine);
• Ar is selected from the group consisting of phenyl, furyl, pyridyl, thienyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, benzofuranyl, indolyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, pyrrolyl, and pyrimidyl, all of which may be unsubstituted or substituted by one or more R4 or R5 groups;
• or, R1 and R6 taken together may constitute a 5 or 6 member cyclic system which may contain an 0 or an optionally substituted N;
• R2 is selected from the group consisting of I, Br, Cl, isopropyl and tert-butyl;
• R3 is selected from the group consisting of H, I, Br, Cl, isopropyl, tert-butyl and Z-R8;
• Z is selected from the group consisting of O, N, —NC(O), —C(O)N, —SO2N, —CONHSO2, —CONHNHCO and —CH2;
• R4 and R5 are independently selected from the group consisting of hydrogen, —OR9, —CN, F, Cl, Br, I, —CO2H, —C(O)NR1R6, —NR6COR6, —NH2, and —C1-4alkyl which may be unsubstituted or substituted by one or more alcohol, amine, amide or carboxylic acid moieties;
• R9 is H, —CH3 or —CF3;
• R7 is selected from the group consisting of hydrogen, —C1-4acyl and —C1-4alkoxycarbonyl;
• R8 is selected from the group consisting of C1-4alkyl which may be unsubstituted or substituted by one or more alcohol, amine, amide, carboxylic acid, aryl or carbocycle.