Socs (suppressor of cytokine signaling)
OwnerLuis A. Parodiinventor
Life of this patent
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Abstract
The present invention provides a cDNA encoding a heretofore unknown polypeptide termed SOCS-8; constructs and recombinant host cells incorporating the cDNA; the SOCS-8 polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing.
Claims28
An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence encoding a SOCS-8 polypeptide having the amino acid sequence of SEQ ID NO:2
An isolated nucleic acid molecule encoding a SOCS-8 polypeptide comprising a polynucleotide that hybridizes under stringent conditions to a polynucleotide having the nucleotide sequence set forth in SEQ ID NO:
- 1
An isolated nucleic acid molecule encoding a SOCS-8 polypeptide comprising a polynucleotide having a sequence at least 95% identical to a polynucleotide having the nucleotide sequence set forth in SEQ ID NO:
- 1
An isolated SOCS-8 polypeptide comprising an amino acid sequence of a SOCS-8 polypeptide having the amino acid sequence of SEQ ID NO:2 and conservative substitutions therein;
An isolated SOCS-8 polypeptide expressed from an isolated nucleic acid molecule comprising a polynucleotide having a sequence at least 95% identical to a polynucleotide having the nucleotide sequence of SEQ ID NO:
- 1;
A isolated SOCS-8 polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2, or a fragment thereof comprising an epitope specific to said polypeptide.
A method for identifying agents that modulate the propensity of a SOCS-8 polypeptide to associate with a binding partner polypeptide comprising
- (a) contacting said SOCS-8 polypeptide and said binding partner polypeptide in the presence and absence of a test agent;
- (b) determining the propensity of said SOCS-8 polypeptide to associate with a said binding partner polypeptide in the presence and absence of the test agent;
- and
- (c) comparing the propensity of said SOCS-8 polypeptide to associate with said binding partner polypeptide in the presence of the test agent with the propensity of said SOCS-8 polypeptide to associate with a said binding partner polypeptide in the absence of the test agent to identify an agent that modulates the propensity of said SOCS-8 polypeptide to associate with a said binding partner polypeptide, wherein an agent which alters the propensity of said SOCS-8 polypeptide to associate with a said binding partner polypeptide is a modulator
27 The method of claim 24, wherein said agent increases activity.
A method for detecting the presence of a SOCS-8 polypeptide comprising the step of contacting said polypeptide with an antibody specific for said polypeptide, under conditions wherein the antibody binds the enzyme.
Dependencies are inferred from the claim text.