Methods of crystal optimisation
AssigneeImperial College Innovations Limited
InventorNaomi E. Chayen
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Abstract
The present invention provides an automated method of optimising crystallisation conditions for macromolecules comprising forming a trial comprising a sample comprising a gel forming component and the macromelecule to be crystallised, wherein at least one component of the trial is dispensed using an automatic liquid dispensing system.
Claims41
An automated method of optimising cystallisation conditions for macromolecules comprising the step of forming a crystallisation trial, the trial comprising a sample comprising (i) a gel forming component and (ii) the macromolecule to be crystallised, wherein at least one component of the trial is dispensed using an automatic liquid dispensing system.
Use of an automated liquid dispensing system capable of dispensing volumes of liquid between 0.1 μl to 5 μl for dispensing a sample of gel-forming component and a macromolecule to be crystallised.
Use of a gel-forming component in automated optimisation of crystallisation of macromolecules.
A kit of parts comprising an automated liquid dispensing system and a gel-forming component.
A kit of parts comprising an automated liquid dispensing system, low density oil and grease.
A method, use or kit according to any one of the previous claims wherein the macromolecule is a biological macromolecule.
Dependencies are inferred from the claim text.