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US 2004/0106763 A1Published application
Linear block polymer
OwnerPer Flodin, Carl-Johan Aurellinventors
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OwnerPer Flodin, Carl-Johan Aurellinventors
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The present invention relates to a linear block polymer having a molecular weight of at least 104 Dalton, which linear block polymer is comprised of internally linearly connected sequences, which sequences may be described according to formula (1), wherein 1 to 100% of R1, which 1 to 100 % of R1 may be the same or different, comprise a functional group Z and each Z, which Z may be the same or different is a protected or unprotected functional group such as hydroxyl, amino, carboxyl, thiol, cyano, or nitro group; and, each R2, which R2 may be same or different, may be derived from a diisocyanate and comprises no, one or more ester groups; each R3, which R3 may be same or different, comprises no, one or more ester groups and may be derived from one or more of polyesterdiol, polyetherdiol or monodiol; method for preparation and fractional precipitation, implants, material for promotion of wound healing, pharmaceutical compositions, microencapsules, suspensions and emulsions. 1
A linear block polymer having a molecular weight of at least 104 Dalton, which linear block polymer is comprised of internally linearly connected sequences, which sequences may be described according to formula (1)
A linear block polymer according to any one of preceding claims, wherein each R1, which R1 may be the same or different, comprises a segment which may be described according to formula (1a).
A linear block polymer according to any one of preceding claims, wherein each R2, which R2 may be the same or different, may be derived from diphenylmethanediisocyanat (MDI), hexamethylenediisocyanat (HDI), 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane (H12MDI) or ethyl-2,6-diisocyanatohexanoate (LDI).
A linear block polymer according to any one of preceding claims, wherein R3 may be derived from one or more of polytetramethyleneoxidediol, polyethyleneoxidediol, polycaprolactonediol, polyethyleneglycoladipatediol, polyldiethyleneglycoladipatdiol, glycerinemonoallylether, trimethylolpropanemonallylether, glycerinemonoglycidylether, dimethylolpropionacid methylester, dimethylolpropionacidbrombutylester, esters of monocarboxymethyl ethers of glycerine, or trimethylpropane.
A linear block polymer according to any one of preceding claims, wherein each Z, which Z may be the same or different, is a hydroxyl, amino, carboxyl, thiol, cyano, or nitro group.
A linear block polymer according to any one of preceding claims, wherein said linear block polymer has a molecular weight of at least 5*104 Dalton.
A linear block polymer according to any one of preceding claims, wherein said linear block polymer comprises a biologically active substance, wherein said biologically active substance is covalently bonded to Z.
A linear block polymer according to any one of preceding claims, wherein said biologically active substance for example may be biologically active peptides e.g. growth factors or GHK, i.e. glycylhistidyllysin, penicillins e.g. benzylpenicillin, fucidin acid or tetracyclins.
Dependencies are inferred from the claim text.