Hydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections

The use of a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt, hydrate or solvate thereof in the preparation of a composition for treatment of bacterial or protozoal infections in humans and non-human mammals:

• 22
• wherein:
• Z represents a radical of formula —N(OH)CH(═O) or formula —C(═O)NH(OH);
• R1 represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula —N(OH)CH(═O), a hydroxy, halo or amino group;
• R2 represents a group R10—(X)n-(ALK)m— wherein
• R10 represents hydrogen, or a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, mercapto, (C1-C6)alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, cyano, nitro, oxo, —COOH, —CONH2, —COORA, —NHCORA, —CONHRA, —NHRA, —NRARB, or —CONRARB wherein RA and RB are independently a (C1-C6)alkyl group and
• ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent —NH—, —O— or —S— linkages,
• X represents —NH—, —O— or —S—, and
• m and n are independently 0 or 1;
• R3 represents the side chain of a natural or non-natural alpha amino acid;
• and
• R4 represents hydrogen, (C1-C6)alkyl or phenyl(C1-C6)alkyl-;
• and
• (a) R5 and R6 independently represent:
• hydrogen, halogen, trifluoromethyl, or
• (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, aryl, heterocyclyl, aryl(C1-C6)alkyl-, or heterocyclyl(C1-C6)alkyl-, any of which may be optionally substituted by
• (C1-C6)alkyl, halogen, trifluoromethyl, cyano, nitro, oxo,
• phenoxy or phenylthio-,
• —ORA, —SRA, —NHRA, —NRARB, —NHCORA—CONHRA, —CONRARB, or —COORA, wherein
• RA and RB are independently hydrogen or (C1-C4)alkyl,
• or in the case where RA and RB are attached to a nitrogen atom then RA and RB taken together with the nitrogen atom to which they are attached form a monocyclic 5-7 membered ring;
• or
• (b) R5 and R6 taken together with the carbon atoms to which they are attached form a fused monocyclic or bicyclic carbocyclic or heterocyclic ring which may be further substituted with any of the substituent groups listed under (a).