Back to results
US 2004/0106665 A1Published application
Resolution process for preparation of substantially pure (r) and (s) enantiomers of 2-(4-nitroimidazolyl)-4-methodxyphenylpropionic acid and salts thereof
OwnerThomas Joseph Kress, Roger Lewis Robey +3inventors
InventorsThomas Joseph Kress, Roger Lewis Robey, James Patrick Wepsiec, Charles Arthur Wepsiec, Gary Anthony Rhodes
Life of this patent
Estimating the term…
Abstract
A method for optically resolving a racemic mixture of 2-(4-nitroimidazolyl)-4-methoxyphenylproprionic acid to substantially pure (R) and (S) enantiomers salts thereof which are useful intermediates in the preparation of certain growth hormone secretagogues.
Claims9
A method for obtaining a single enantiomer of nitroimidazolyl methoxyphenylpropionic acid of Formula A:
- 14
- comprising the steps of:
- (a) reacting a racemic mixture of a compound of Formula A with a resolving agent selected from the group consisting of levamisole, quinidine, brucine, (+)-cinchonine, (−)-cinchonidine, (1R,2S)-ephedrine and (1S,2R)-ephedrine in a solvent to produce a crystalline salt;
- (b) isolating the crystalline salt;
- and
- (c) optionally converting the crystalline salt to free acid thereby producing a substantially pure R or S enantiomer.
3 more elements
Dependencies are inferred from the claim text.