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US 2004/0106663 A1Published application
Inhibitors of fungal invasion
OwnerJohn Jeffrey Talley, Angelika Fretzen +9inventors
InventorsJohn Jeffrey Talley, Angelika Fretzen, Craig Zimmerman, Timothy Barden, Jing Jing Yang, Eduardo Martinez, Robert Busby, Etchell A. Cordero, Fariba Houman Cipriano, Christine M. Pierce, Eric F. Summers
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Abstract
This invention relates to isoxazole-based inhibitors of fungal invasion.
Claims40
A compound having a formula (I):
- 313
- or a pharmaceutically acceptable salt thereof, wherein,
- each of R1 and R2 is, independently, H, substituted or unsubstituted C1-6 alkyl, or substituted or unsubstituted C1-6 alkoxy, wherein the substituents are selected from the group consisting of hydroxy and halo;
- R3 is H, formyl, acetyl, or substituted or unsubstituted C1-3 alkyl, wherein the substituents are selected from the group consisting of hydroxy and halo;
- each of R4—R8 is, independently, H, halo, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted C1-6 alkoxy, substituted or unsubstituted C2-12 alkenyloxy, substituted or unsubstituted C5-10 cycloalkenyloxy, substituted or unsubstituted (C2-12 alkynyl)oxy, (C1-6 alkyl)oxy(C1-6 alkyl), substituted or unsubstituted C6-12 aryloxy, (C3-6 heteroaryl)-(C1-6 alkyl)oxy, (C1-12 alkyl)thio, substituted or unsubstituted (C1-4 alkyl)-thio-(C1-4 alkyl), substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted styryl, substituted or unsubstituted C3-12 heteroaryl, substituted or unsubstituted C4-8 heterocyclic, —NH—C(O)—NH-(substituted or unsubstituted heteroaryl), or —NR19R20, wherein each of R19 and R20 is, independently, H, C1-12 alkyl, or C2-12 alkenyl, wherein the substituents are selected from the group consisting of hydroxy, halo, C1-4 alkyl, C1-4 trihaloalkyl, C1-6 alkoxy, C1-4 trihaloalkoxy, bivalent oxyalkyloxy, acylamino, acylthio, amino, and azido;
- or R5 and R6 form a C5-C10 heteroaryl ring, and each of R4, R7, and R8 is, independently, hydroxy, halo, C1-4 alkyl, C1-4 trihaloalkyl, C1-6 alkoxy, or C1-4 trihaloalkoxy;
- provided that at least one of R4-R8 is not H;
- further provided that when R1 is alkyl, then R6 is not butyl;
- further provided that when R1 is methyl and R2 is H, then R6 is not —C≡CH, —NHCH3, CF3, or —CH2CH3.
6 more elements
A compound having a formula (II):
- 314
- or a pharmaceutically acceptable salt thereof, wherein
- each of R21 and R22 is, independently, substituted or unsubstituted C1-6 alkyl, or substituted or unsubstituted C1-6 alkoxy, wherein the substituents are selected from the group consisting of hydroxy and halo;
- R23 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C6-12 aryl, substituted or unsubstituted C3-12 heteroaryl, wherein the substituents are selected from the group consisting of halo, C1-6 alkyl, and C1-6 trihaloalkyl.
1 more element
Dependencies are inferred from the claim text.