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US 2004/0106657 A1Published application
Indolyl derivatives
AssigneeHoffmann-La Roche Inc.
InventorsAlfred Binggeli, Uwe Grether, Hans Hilpert, Georges Hirth, Bernd Kuhn, Hans-Peter Maerki, Markus Meyer, Peter Mohr
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Abstract
The present invention provides compounds of formula I 1 as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4, A and n have the significance given in the specification. The compounds or their salts may be administered to a patient for treating non-insulin dependent diabetes mellitus.
Claims20
A compound of formula (I)
- 18
- wherein
- R1 is unsubstituted naphthyl,
- unsubstituted phenyl,
- phenyl substituted with one or more substituents each independently selected from halogen, trifluoromethyl, amino, alkyl, alkoxy, alkylcarbonyl, cyano, carbamoyl, alkoxycarbamoyl) methylendioxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkyaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkyl substituted with one to three halogen atoms, and nitro,
- unsubstituted heteroaryl which contains one or two hetero atoms selected from nitrogen, oxygen and sulfur,
- or substituted heteroaryl which is heteroaryl which contains one or two hetero atoms selected from nitrogen, oxygen and sulfur and which is substituted on at least one carbon atom with a group independently selected from halogen, alkyl, alkoxy, cyano, haloalkyl and trifluoromethyl;
- R2 is hydrogen, alkyl or cycloalkyl;
- R3 is alkoxy or alkoxy substituted with one to three halogen atoms;
- R4 is hydrogen, alkyl or cycloalkyl;
- A is oxygen or sulfur;
- n is 1, 2 or 3;
- wherein the bond between the carbon atoms Ca and Cb is a carbon carbon single or double bond;
- and pharmaceutically acceptable salts and esters thereof.
11 more elements
Dependencies are inferred from the claim text.