Inhibitors of copper-containing amine oxidases

A method of treating an inflammatory disease or condition, a disease related to carbohydrate metabolism, a disease related to aberrations in adipocyte differentiation or function or smooth muscle cell function, or a vascular disease, comprising administering to an animal in need of such treatment an effective amount of a compound of Formula I or Formula II:

• 48
• or a stereoisomer or pharmaceutically acceptable solvate, hydrate, or salt thereof;
• wherein:
• R1 is hydrogen, (C1-C4)alkyl, aralkyl, (C2-C5)alkanoyl, aroyl or heteroaroyl;
• R2 is hydrogen, or optionally substituted (C1-C4)alkyl, optionally substituted cycloalkyl or optionally substituted aralkyl;
• R3-R6, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, optionally substituted aralkyl, optionally substituted phenyl or optionally substituted heteroaryl;
• or R1 and R2, together with the atoms to which they are attached, represent an optionally substituted heterocycle,
• or R2 and R3, together with the atoms to which they are attached, represent an optionally substituted heterocycle,
• or R3 and R5, together with the atoms to which they are attached, represent a saturated, optionally substituted carbocycle;
• R7 is hydrogen, (C1-C4)alkyl, (C2-C5)alkanoyl or aralkyl;
• R8 is (C1-C4)alkyl or aralkyl;
• n is 1, 2 or 3;
• and
• X is chloride, bromide, iodide or R2-sulfate, where R2 is as defined herein.