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US 2004/0106652 A1Published application
Heterocyclic ketone and thioester compounds and uses
AssigneeGPI NIL Holdings, Inc.
InventorsGregory S. Hamilton, Jia-He Li
Life of this patent
Estimating the term…
Abstract
This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
Claims83
A neurotrophic, low molecular weight, small molecule heterocyclic ketone or thioester compound.
A compound of formula II:
- 12
- or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein:
- n is 1 or 2;
- X is O or S;
- Z is selected from the group consisting of CH2, CHR1 and CR1R2;
- R1, R2, and R3 are independently selected from the group consisting of C1-C5 straight or branched chain alkyl, C2-C5 straight or branched chain alkenyl, and Ar, wherein said R1, R2, or R3 is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, nitro, C1-C6 straight or branched chain alkyl, C2-C6 straight or branched chain alkenyl, hydroxy, C1-C4 alkoxy, C2-C4 alkenyloxy, phenoxy, benzyloxy, amino, and Ar;
- R4 is selected from the group consisting of C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, and Ar;
- and
- Ar is aryl, wherein said Ar is unsubstituted or substituted with halo, trifluoromethyl, hydroxy, nitro, C1-C6 straight or branched chain alkyl, C2-C6 straight or branched chain alkenyl, C1-C4 alkoxy, C2-C4 alkenyloxy, phenoxy, benzyloxy, or amino.
6 more elements
The method of claim 61, wherein said compound is (2S)-3,3-dimethyl-1-[2-(5-(3-pyridyl) pyrrolidinyl]pentane-1,2-dione, or a pharmaceutically acceptable salt, ester, or solvate thereof.
Dependencies are inferred from the claim text.