Antiproliferative agents
AssigneeEPX Research Limited
InventorsWashington Odur Ayuko, Michael John Tisdale, Eric Lattmann
Life of this patent
Estimating the term…
Abstract
This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents, especially tumour growth inhibitors and anti-cancer agents, antibiotics and/or antiviral agents.
Claims20
A compound of the general formula
- 12
- in which
- R1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl group;
- R2 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, acyl, heterocyclyl or heterocyclylalkyl group;
- and
- W and X each independently represents a hydrogen or halogen atom.
3,4-Dichloro-6-hydroxy-1-methyl-2,5-dioxo-1,6-dihydropyridine.
A compound of the general formula IIA or IIB
- 15
- or a salt thereof, in which
- R1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl group;
- R2 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, acyl, heterocyclyl or heterocyclylalkyl group;
- and
- W and X each independently represents a hydrogen or halogen atom and Y represents a hydrogen atom, a hydroxyl group or a group -OM where M represents an alkali metal atom,
- with the proviso that, when R1, W and X all represent a hydrogen atom and Y represents a hydroxyl group, then R2 is not hydrogen, methyl or chloromethyl.
(Z)-2,3-dichloro-4-[N-formyl-N-methylamino]4-oxo-but-2-enoic acid.
A compound of the general formula IV
- 17
- in which
- R1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl group;
- R2 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, acyl, heterocyclyl or heterocyclylalkyl group;
- and
- W and X each independently represents a hydrogen or halogen atom and
- R3 represents an optionally substituted alkyl, aryl or aralkyl group.
5-[N-formyl-N-methylamino]-3,4-dichloro-2-furyl-2,2-dichloroacetate.
Dependencies are inferred from the claim text.