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US 2004/0106637 A1Published application
Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
AssigneeThe Regents of the University of Michigan
InventorKun-Liang Guan
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Abstract
The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.
Claims18
A method of detecting increased S6 kinase activity in a subject, comprising:
- a) providing a biological sample from a subject;
- and
- b) detecting the presence or absence of increased S6 kinase activity in said biological sample.
A method of screening compounds, comprising:
- a) providing
- i) a cell expressing S6 kinase;
- and
- ii) one or more test compounds;
- and
- b) screening said test compounds for the ability to inhibit the kinase activity of said S6 kinase.
3 more elements
A method of treating a disease, comprising:
- a) providing:
- i) a subject, wherein said subject suffers from a disease, wherein said disease comprises defective cells, wherein said defective cells comprise a defective TSC pathway;
- ii) an agent;
- wherein said agent reduces cellular ATP levels;
- and
- b) administering said agent to said subject;
- wherein said agent targets said defective cells.
4 more elements
Dependencies are inferred from the claim text.