Spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

A compound of formula (I),

• 9
• wherein
• m is 1, 2 or 3;
• R1 is methyl, chloro, bromo or fluoro;
• R2 is -Q1-Q2-Q3-Q4 or (C1-C6)alkyl,
• said (C1-C6)alkyl is substituted with one to three OR4, COOR4, NR4R5, NRC(═O)R4, C(═O)NR4R5 or SO2NR4R5;
• R4 is (C1-C6)alkyl substituted with one to three F, CN, S(═O)R6, SO3H, SO2R6, SR7, C(═O)—NH—SO2—CH3, C(═O)R7, NR′C(═O)R7, NR′SO2R6, C(═O)NR7R8, O—C(═O)NR7R8 or SO2NR7R8;
• R5 is H or (C1-C6)alkyl optionally substituted with one to three F, CN, S(═O)R6, SO3H, SO2R6, SR7, C(═O)—NH—SO2—CH3, C(═O)R7, NR′C(═O)R7, NR′SO2R6, C(═O)NR7R8, O—C(═O)NR7R8 or SO2NR7R8;
• or
• said (C1-C6)alkyl is
• 1) substituted with one to three OC(═O)R4a, SR4a, S(═O)R3, C(═NR9)R4a, C(═NR9)—NR4aR5a, NR—C(═NR9)—NR4aR5a, NRCOOR4a, NR—C(═O)—NR4aR5a, NR—SO2—NR4aR5a, NR—C(═NR9)—R4aor NR—SO2—R3;
• and
• 2) optionally substituted with one or two OR4a, COOR4a, C(═O)—R4a, NR4aR5a, NRC(═O)R4a, C(═O)NR4R5aor SO2NR4aR5a;
• R9 is H, CN, OH, OCH3, SO2CH3, SO2NH2 or (C1-C6)alkyl;
• and R3 is (C1-C6)alkyl optionally substituted with one to three F, CN, S(═O)R6, SO3H, SO2R6, C(═O)—NH—SO2—CH3, OR7, SR7, COOR7, C(═O)R7, O—C(═O)NR7R8, NR7R8, NR′C(═O)R7, NR′SO2R6, C(═O)NR7R8 or SO2NR7R8;
• R4aand R5a are the same or different and are H or (C1-C6)alkyl optionally substituted with one to three F, CN, S(═O)R6, SO3H, SO2R6, C(═O)—NH—SO2—CH3, OR7, SR7, COOR7, C(═O)R7, O—C(═O)NR7R8, NR7R8, NR′C(═O)R7, NR′SO2R6, C(═O)NR7R8 or SO2NR7R8;
• Q1 is a single bond or (C1-C6)alkylene;
• Q2 is a saturated 4- to 6-membered heterocyclyl comprising one or two O or N;
• Q3 is (C1-C6)alkylene;
• Q4 is a 4 to 8-membered, aromatic or non aromatic, heterocyclyl comprising 1 to 4—O—, —S—, —S(═O)—, —SO2— or —N—, said heterocyclyl being optionally substituted with one to three —OR, —NRR′, —CN or —(C1-C6)alkyl;
• R is H or (C1-C6)alkyl;
• R6 is (C1-C6)alkyl optionally substituted with one or two —OR′;
• R7 and R8 are the same or different and are H or (C1-C6)alkyl optionally substituted with one or two —OR′;
• R9 is H, —CN, —OH, —OCH3, —SO2CH3, —SO2NH2 or —(C1-C6)alkyl;
• R′ is H or (C1-C6)alkyl;
• and
• R″ is H or (C1-C6)alkyl;
• provided that
• 1) the atom of Q2 bound to Q1 is a carbon atom;
• and
• 2) the atom of Q4 bound to Q3 is a carbon atom;
• or a racemic form, isomer, pharmaceutically acceptable derivative thereof.