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AssigneeMerck & Co., Inc.
InventorsCristina Gardelli, Claudio Giuliano, Steven Harper, Uwe Koch, Frank Narjes, Jesus Maria Ontoria Ontoria, Marco Poma, Simona Ponzi, Ian Stansfield, Vincenzo Summa
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A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclic group; as well as compounds of formula (I) which are derivatised at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme. 1
A compound of formula (I), or a tautomer thereof, as well as pharmaceutically acceptable salts and esters thereof:
A compound selected from Example Nos. 1-7, 42-467, 469-568 and 570-593, or a tautomer thereof, or a pharmaceutically acceptable salt or ester thereof.
A compound selected from Example Nos. 8, 9, 594-627, 629 and 631-652, or a tautomer thereof, or a pharmaceutically acceptable salt or ester thereof.
Dependencies are inferred from the claim text.