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US 2004/0106607 A1Published application
New compounds
AssigneeAstraZeneca AB and NPS Pharmaceuticals, Inc.
InventorsJalaj Arora, Louise Edwards, Methvin Isaac, Abdelmalik Slassi, Tomislav Stefanac, David Wensbo, Tao Xin
Life of this patent
Estimating the term…
Abstract
The present invention relates to new compounds of formula I, 1 wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4, R5, G, M1, M2, M3, m and n, are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
Claims23
A compound having the formula I
- 7
- wherein:
- P is selected from the group consisting of C3-7alkyl and a 3- to 8-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be fused with a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S;
- R1 is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C1-6alkylhalo, OC1-6alkylhalo, C1-6alkyl, OC1-6alkyl, C2-6alkenyl, OC2-6alkenyl, C2-6alkylnyl, OC2-6alkynyl, C0-6alkylC3-6cycloalkyl, OC0-6alkylC3-6cycloalkyl, C0-6alkylaryl, OC0-6alkylaryl, (CO)R8, O(CO)R8, O(CO)OR8, C1-6alkylOR8, OC2-6alkylOR8, C1-6alkyl(CO)R8, OC1-6alkyl(CO)R8, C0-6alkylCO2R8, OC1-6alkylCO2R8, C0-6alkylcyano, OC2-6alkylcyano, C0-6alkylNR8R9, OC2-6alkylNR8R9, C1-6alkyl(CO)NR8R9, OC1-6alkyl(CO)NR8R9, C0-6alkylNR8(CO)R9, OC2-6alkylNR8(CO)R9, C0-6alkylNR8(CO)NR8R9, C0-6alkylSR8, OC2-6alkylSR8, C0-6alkyl(SO)R8, OC2-6alkyl(SO)R8, C0-6alkylSO2R8, OC2-6alkylSO2R8, C0-6alkyl(SO2)NR8R9, OC2-6alkyl(SO2)NR8R9, C0-6alkylNR8(SO2)R9, OC2-6alkylNR8(SO2)R9, C0-6alkylNR8(SO2)NR8R9, OC2-6alkylNR8(SO2)NR8R9, (CO)NR8R9, O(CO)NR8R9, NR8OR9, C0-6alkylNR8(CO)OR9, OC0-6alkylNR8(CO)OR9, SO3R8 and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be substituted by one or more A;
- M1 is selected from the group consisting of a bond, C1-3alkyl, C2-3alkenyl, C2-3alkynyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-3alkyl(CO)NR8, C0-3alkyl(CO)NR8C1-3alkyl, C0-4alkylNR8R9, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R2 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- X1, X2 and X3 are independently selected from N, NR, O, CR, ═O and S;
- R is selected from the group consisting of hydrogen, C0-3alkyl, halo, C0-3alkylOR5, C0-3alkylNR5R6, C0-3alkyl(CO)OR5, C0-3alkylNR5R6 and C0-3alkylaryl;
- M2 is selected from the group consisting of a bond, C1-3alkyl, C2-3alkenyl, C2-3alkynyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-3alkylNR8C1-3alkyl, C0-3alkyl(CO)NR8, C0-4alkylNR8R9, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R3 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- Q is a 4-, 5-, 6- or 7-membered ring containing one or more heteroatoms independently selected from N, O or S, wherein said ring may be fused with a 3-, 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein the fused ring may be substituted by one or more A;
- X4 is selected from the group consisting of C, CR, N;
- R4 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, OC0-6alkylaryl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C1-4alkylOR8, C0-4alkylcyano and C0-4alkylNR8R9;
- M3 is selected from the group consisting of a bond, C1-4alkyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-4alkylNR8R9, C0-3alkylNR8C1-3alkyl, C0-3alkly(CO)NR8, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R5 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- G is selected from the group consisting of R6 and R7;
- R6 is selected from the group consisting of hydrogen and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be fused with a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein any of the rings may be substituted by one or more is A;
- R7 is selected from the group consisting of hydrogen, C0-4alkylcyano, C═NR8(NR8R9), C═NOR8(NR8R9), NR8C═NR8(NR8R9), NR8(C═CCN)(NR8R9), NR8(C═CNO2)(NR8R9), NR8(C═NCN)(NR8R9), CONR8R9 and NR8(CO)NR8R9;
- R8 and R9 are independently selected from hydrogen, C1-6alkyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-6alkylheteroaryl and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein R8 and R9 may together form a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S;
- wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-6alkylheteroary and 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S as defined under R1, R2, R3, R4, R5, R6, R7, R8, and R9 may be substituted by one or more A;
- A is selected from the group consisting of hydrogen, hydroxy, oxo, halo, nitro, C1-6alkyl, C0-6alkylC3-6cycloalkyl, C1-6alkylhalo, OC1-6alkylhalo, C2-6alkenyl, OC1-6alkyl, C0-3alkylaryl, C1-6alkylOR8, OC2-6alkylOR8, C1-6alkylSR8, OC2-6alkylSR8, (CO)R8, O(CO)R8, OC2-6alkylcyano, C0-6alkylcyano, C0-6alkylCO2R8, OC1-6alkylCO2R8, O(CO)OR8, OC1-6alkyl(CO)R8, C1-6alkyl(CO)R8, NR8OR9, C0-6alkylNR8R9, OC2-6alkylNR8R9, C0-6alkyl(CO)NR8R9, OC1-6alkyl(CO)NR8R9, OC2-6alkylNR8(CO)R9, C0-6alkylNR8(CO)R9, C0-6alkylNR8(CO)NR8R9, O(CO)NR8R9, NR8(CO)OR9, C0-6alkyl(SO2)NR8R9, OC2-6alkyl(SO2)NR8R9, C0-6alkylNR8(SO2)R9, OC2-6alkylNR8(SO2)R9, SO3R8, C1-6alkylNR8(SO2)NR8R9, OC2-6alkyl(SO2)R8, C0-6alkyl(SO2)R8, C0-6alkyl(SO)R8 and OC2-6alkyl(SO)R8;
- m is selected from 0, 1, 2, 3 or 4;
- and
- n is selected from 0, 1, 2 or 3;
- or salt thereof.
22 more elements
A process for the preparation of a compound of formula Ia comprising:
- (a) aminating a compound of formula VI:
- 8
- with a reagent of the formula G—C(R5)═O, and
- (b) reducing the resultant product with a reducing agent to give the compound of formula Ia:
- 9
- wherein:
- P is selected from the group consisting of C3-7alkyl and a 3- to 8-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be fused with a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S;
- R1 is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C1-6alkylhalo, OC1-6alkylhalo, C1-6alkyl, OC1-6alkyl, C2-6alkenyl, OC2-6alkenyl, C2-6alkylnyl, OC2-6alkynyl, C0-6alkylC3-6cycloalkyl, OC0-6alkylC3-6cycloalkyl, C0-6alkylaryl, OC0-6alkylaryl, (CO)R8, O(CO)R8, O(CO)OR8, C1-6alkylOR8, OC2-6alkylOR8, C1-6alkyl(CO)R8, OC1-6alkyl(CO)R8, C0-6alkylCO2R8, OC1-6alkylCO2R8, C0-6alkylcyano, OC2-6alkylcyano, C0-6alkylNR8R9, OC2-6alkylNR8R9, C1-6alkyl(CO)NR8R9, OC1-6alkyl(CO)NR8R9, C0-6alkylNR8(CO)R9, OC2-6alkylNR8(CO)R9, C0-6alkylNR8(CO)NR8R9, C0-6alkylSR8, OC2-6alkylSR8, C0-6alkyl(SO)R8, OC2-6alkyl(SO)R8, C0-6alkylSO2R8, OC2-6alkylSO2R8, C0-6alkyl(SO2)NR8R9, OC2-6alkyl(SO2)NR8R9, C0-6alkylNR8(SO2)R9, OC2-6alkylNR8(SO2)R9, C0-6alkylNR8(SO2)NR8R9, OC2-6alkylNR8(SO2)NR8R9, (CO)NR8R9, O(CO)NR8R9, NR8OR9, C0-6alkylNR8(CO)OR9, OC0-6alkylNR8(CO)OR9, SO3R8 and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be substituted by one or more A;
- M1 is selected from the group consisting of a bond, C1-3alkyl, C2-3alkenyl, C2-3alkynyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-3alkyl(CO)NR8, C0-3alkyl(CO)NR8C1-3alkyl, C0-4alkylNR8R9, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R2 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- X1, X2 and X3 are independently selected from N, NR, O, CR, ═O and S;
- R is selected from the group consisting of hydrogen, C0-3alkyl, halo, C0-3alkylOR5, C0-3alkylNR5R6, C0-3alkyl(CO)OR5, C0-3alkylNR5R6 and C0-3alkylaryl;
- M2 is selected from the group consisting of a bond, C1-3alkyl, C2-3alkenyl, C2-3alkynyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-3alkylNR8C1-3alkyl, C0-3alkyl(CO)NR8, C0-4alkylNR8R9, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R3 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- Q is a 4-, 5-, 6- or 7-membered ring containing one or more heteroatoms independently selected from N, O or S, wherein said ring may be fused with a 3-, 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein the fused ring may be substituted by one or more A;
- R4 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, OC0-6alkylaryl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C1-4alkylOR8, C0-4alkylcyano and C0-4alkylNR8R9;
- M3 is selected from the group consisting of a bond, C1-4alkyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-4alkylNR8R9, C0-3alkylNR8C1-3alkyl, C0-3alkly(CO)NR8, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R5 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- G is selected from the group consisting of R6 and R7;
- R6 is selected from the group consisting of hydrogen and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be fused with a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein any of the rings may be substituted by one or more A;
- R7 is selected from the group consisting of hydrogen, C0-4alkylcyano, C═NR8(NR8R9), C═NOR8(NR8R9), NR8C═NR8(NR8R9), NR8(C═CCN)(NR8R9), NR8(C═CNO2)(NR8R9), NR8(C═NCN)(NR8R9), CONR8R9 and NR8(CO)NR8R9;
- R8 and R9 are independently selected from hydrogen, C1-6alkyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-6alkylheteroaryl and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein R8 and R9 may together form a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S;
- wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-6alkylheteroary and 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S as defined under R1, R2, R3, R4, R5, R6, R7, R8, and R9 may be substituted by one or more A;
- A is selected from the group consisting of hydrogen, hydroxy, oxo, halo, nitro, C1-6alkyl, C0-6alkylC3-6cycloalkyl, C1-6alkylhalo, OC1-6alkylhalo, C2-6alkenyl, OC1-6alkyl, C0-3alkylaryl, C1-6alkylOR8, OC2-6alkylOR8, C1-6alkylSR8, OC2-6alkylSR8, (CO)R8, O(CO)R8, OC2-6alkylcyano, C0-6alkylcyano, C0-6alkylCO2R8, OC1-6alkylCO2R8, O(CO)OR8, OC1-6alkyl(CO)R8, C1-6alkyl(CO)R8, NR8OR9, C0-6alkylNR8R9, OC2-6alkylNR8R9, C0-6alkyl(CO)NR8R9, OC1-6alkyl(CO)NR8R9, OC2-6alkylNR8(CO)R9, C0-6alkylNR8(CO)R9, C0-6alkylNR8(CO)NR8R9, O(CO)NR8R9, NR8(CO)OR9, C0-6alkyl(SO2)NR8R9, OC2-6alkyl(SO2)NR8R9, C0-6alkylNR8(SO2)R9, OC2-6alkylNR8(SO2)R9, SO3R8, C1-6alkylNR8(SO2)NR8R9, OC2-6alkyl(SO2)R8, C0-6alkyl(SO2)R8, C0-6alkyl(SO)R8 and OC2-6alkyl(SO)R8;
- m is selected from 0, 1, 2, 3 or 4;
- and
- n is selected from 0, 1, 2 or 3.
24 more elements
A process for the preparation of a compound of formula Ib comprising:
- (a) reacting a compound of formula VIII:
- 10
- with a compound of formula IX:
- 11
- (b) cyclizing the resultant intermediate to give the compound of formula Ib:
- 12
- wherein
- P is selected from the group consisting of C3-7alkyl and a 3- to 8-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be fused with a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S;
- R1 is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C1-6alkylhalo, OC1-6alkylhalo, C1-6alkyl, OC1-6alkyl, C2-6alkenyl, OC2-6alkenyl, C2-6alkylnyl, OC2-6alkynyl, C0-6alkylC3-6cycloalkyl, OC0-6alkylC3-6cycloalkyl, C0-6alkylaryl, OC0-6alkylaryl, (CO)R8, O(CO)R8, O(CO)OR8, C1-6alkylOR8, OC2-6alkylOR8, C1-6alkyl(CO)R8, OC1-6alkyl(CO)R8, C0-6alkylCO2R8, OC1-6alkylCO2R8, C0-6alkylcyano, OC2-6alkylcyano, C0-6alkylNR8R9, OC2-6alkylNR8R9, C1-6alkyl(CO)NR8R9, OC1-6alkyl(CO)NR8R9, C0-6alkylNR8(CO)R9, OC2-6alkylNR8(CO)R9, C0-6alkylNR8(CO)NR8R9, C0-6alkylSR8, OC2-6alkylSR8, C0-6alkyl(SO)R8, OC2-6alkyl(SO)R8, C0-6alkylSO2R8, OC2-6alkylSO2R8, C0-6alkyl(SO2)NR8R9, OC2-6alkyl(SO2)NR8R9, C0-6alkylNR8(SO2)R9, OC2-6alkylNR8(SO2)R9, C0-6alkylNR8(SO2)NR8R9, OC2-6alkylNR8(SO2)NR8R9, (CO)NR8R9, O(CO)NR8R9, NR8OR9, C0-6alkylNR8(CO)OR9, OC0-6alkylNR8(CO)OR9, SO3R8 and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be substituted by one or more A;
- M1 is selected from the group consisting of a bond, C1-3alkyl, C2-3alkenyl, C2-3alkynyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-3alkyl(CO)NR8, C0-3alkyl(CO)NR8C1-3alkyl, C0-4alkylNR8R9, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R2 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- X2 and X3 are independently selected from N, NR, O, CR, ═O and S;
- R is selected from the group consisting of hydrogen, C0-3alkyl, halo, C0-3alkylOR5, C0-3alkylNR5R6, C0-3alkyl(CO)OR5, C0-3alkylNR5R6 and C0-3alkylaryl;
- M2 is selected from the group consisting of a bond, C1-3alkyl, C2-3alkenyl, C2-3alkynyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-3alkylNR8C1-3alkyl, C0-3alkyl(CO)NR8, C0-4alkylNR8R9, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R3 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- Q is a 4-, 5-, 6- or 7-membered ring containing one or more heteroatoms independently selected from N, O or S, wherein said ring may be fused with a 3-, 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein the fused ring may be substituted by one or more A;
- X6 is OC1-3alkyl;
- R4 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, OC0-6alkylaryl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C1-4alkylOR8, C0-4alkylcyano and C0-4alkylNR8R9;
- M3 is selected from the group consisting of a bond, C1-4alkyl, C0-4alkyl(CO)C0-4alkyl, C0-3alkylOC0-3alkyl, C0-4alkylNR8R9, C0-3alkylNR8C1-3alkyl, C0-3alkly(CO)NR8, C0-3alkylSC0-3alkyl, C0-3alkyl(SO)C0-3alkyl and C0-3alkyl(SO2)C0-3alkyl;
- R5 is selected from the group consisting of hydrogen, hydroxy, oxo, ═NR8, ═NOR8, C1-4alkylhalo, halo, C1-4alkyl, O(CO)C1-4alkyl, C1-4alkyl(SO)C0-4alkyl, C1-4alkyl(SO2)C0-4alkyl, (SO)C0-4alkyl, (SO2)C0-4alkyl, OC1-4alkyl, C0-4alkylcyano, C1-4alkylOR8 and C0-4alkylNR8R9;
- G is selected from the group consisting of R6 and R7;
- R6 is selected from the group consisting of hydrogen and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be fused with a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein any of the rings may be substituted by one or more is A;
- R7 is selected from the group consisting of hydrogen, C0-4alkylcyano, C═NR8(NR8R9), C═NOR8(NR8R9), NR8C═NR8(NR8R9), NR8(C═CCN)(NR8R9), NR8(C═CNO2)(NR8R9), NR8(C═NCN)(NR8R9), CONR8R9 and NR8(CO)NR8R9;
- R8 and R9 are independently selected from hydrogen, C1-6alkyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-6alkylheteroaryl and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, and wherein R8 and R9 may together form a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S;
- wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-6alkylheteroary and 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S as defined under R1, R2, R3, R4, R5, R6, R7, R8, and R9 may be substituted by one or more A;
- A is selected from the group consisting of hydrogen, hydroxy, oxo, halo, nitro, C1-6alkyl, C0-6alkylC3-6cycloalkyl, C1-6alkylhalo, OC1-6alkylhalo, C2-6alkenyl, OC1-6alkyl, C0-3alkylaryl, C1-6alkylOR8, OC2-6alkylOR8, C1-6alkylSR8, OC2-6alkylSR8, (CO)R8, O(CO)R8, OC2-6alkylcyano, C0-6alkylcyano, C0-6alkylCO2R8, OC1-6alkylCO2R8, O(CO)OR8, OC1-6alkyl(CO)R8, C1-6alkyl(CO)R8, NR8OR9, C0-6alkylNR8R9, OC2-6alkylNR8R9, C0-6alkyl(CO)NR8R9, OC1-6alkyl(CO)NR8R9, OC2-6alkylNR8(CO)R9, C0-6alkylNR8(CO)R9, C0-6alkylNR8(CO)NR8R9, O(CO)NR8R9, NR8(CO)OR9, C0-6alkyl(SO2)NR8R9, OC2-6alkyl(SO2)NR8R9, C0-6alkylNR8(SO2)R9, OC2-6alkylNR8(SO2)R9, SO3R8, C1-6alkylNR8(SO2)NR8R9, OC2-6alkyl(SO2)R8, C0-6alkyl(SO2)R8, C0-6alkyl(SO)R8 and OC2-6alkyl(SO)R8;
- m is selected from 0, 1, 2, 3 or 4;
- and
- n is selected from 0, 1, 2 or 3.
26 more elements
Dependencies are inferred from the claim text.