Novel fused indazoles and indoles and their use for the treatment of glaucoma

A compound represented by Formula I:

• 8
• wherein R1 and R2 are independently chosen from hydrogen or an alkyl group;
• R3 and R4 are independently chosen from hydrogen, an alkyl group or R3, R4 and the carbon atom to which they are attached form a cycloalkyl ring, or R2 and R3 together represent (CH2)m to form a saturated heterocycle;
• R5 is chosen from hydroxyl, alkoxy, alkyl, halogen, or OC(═O)W;
• R6 is chosen from hydrogen, halogen, a substituted or unsubstituted alkyl group;
• R7 and R8 are hydrogen or an alkyl group;
• W is a substituted or unsubstituted alkyl group, NR7R8, N(R7)CH2(CH2)nN(R7)(R8), O-alkyl, or a substituted or unsubstituted alkenyl;
• m is 3 or 4;
• n is 2 or 3;
• A is a 5- to 7-membered ring optionally containing one heteroatom chosen from NR7, O, or S;
• X is either N or C;
• Y and Z are either N or C, wherein Y and Z are different;
• and
• the dashed bonds denote a suitably appointed single and double bond;
• or pharmaceutically acceptable salts or solvates thereof.