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US 2004/0106596 A1Published application
Pyridoquinoxaline antivirals
OwnerWilliam R. Perraultinventor
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Abstract
The present invention provides a compound of formula I 1 or a pharmaceutically acceptable salt thereof wherein R1 and R2 are as defined in the specification. The compounds are useful for the treatment of viral infections.
Claims26
A compound of formula I
- 10
- or a pharmaceutically acceptable salt thereof
- wherein R1 is F, Cl, Br, CN or NO2;
- R2 is C1-6alkyl, optionally substituted by one to three OR3, NR3R3, aryl or het;
- R3 is H or C1-4 alkyl;
- het is morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyridyl, imidazolyl, azetidyl, tetrahydrofuranyl or imidazolidinyl;
- and aryl is a phenyl or pyridyl radical, attached via a carbon atom, optionally substituted by one to three halogen, OR3 or NR3R3.
4 more elements
12 A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
14 The method of claim 13 wherein the mammal is a human.
A method of preparing an intermediate of formula IV or a pharmaceutically acceptable salt thereof
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- which comprises reacting a compound of formula m or its pharmaceutically acceptable salt thereof
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- with hydroxide or alkoxide in an aqueous solvent;
- wherein R2 is C1-6alkyl, optionally substituted by one to three OR3, NR3R3, aryl or het;
- R3 is H or C1-4 alkyl;
- het is morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyridyl, imidazolyl, azetidyl, tetrahydrofuranyl or imidazolidinyl;
- and aryl is a phenyl or pyridyl radical, attached via a carbon atom, optionally substituted by one to three halogen, OR3 or NR3R3.
5 more elements
Dependencies are inferred from the claim text.