2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof

2H-1-Benzopyran derivatives of general formula:

• 57
• wherein R1 and R2 are independently H, alkyl, haloalkyl, alkenyl or haloalkenyl, or, when they are alkyl, together with nitrogen atom they are bound to, they can form a 4- to 8-membered heterocyclic ring
• X is H, alkyl, aryl, nitro, halo, O—R3 wherein R3 is H, alkyl, aryl, alkanoyl, aryloyl
• X1 is H, alkyl or alkoxy and when X and X1 are alkyl they can form, together with the carbon atom they are bound to, a fused aromatic ring to give an α-naphthalenyl
• Y is H, alkyl, alkanoyl, aryloyl, alkylaminocarbonyl, alkyloxycarbonyl
• Z is H, O—R4 wherein R4 is H, alkyl, alkanoyl, aryloyl
• m is 1,2
• n is 0,1
• p is 2-6
• represents a single or double bond between the atoms in positions 3-4 or 4-4a:
• when n is 1 the double bond may be alternatively exocyclic or endocyclic to give respectively a 4-benzylidenechroman for m=1 or a 4-benzyl-chrom-3-ene for m=2;
• when n is 0 the endocyclic bond 3-4 may be a single or a double bond and when n is 0 and the endocyclic bond 3-4 is a single bond, Z is not H,
• and the pharmaceutically acceptable salts thereof.