Phenyl heterocyclyl ethers

A compound of general formula (I), pharmaceutically acceptable salts, solvates or polymorphs thereof;

• 210
• wherein;
• L and U, which may be the same or different, are —N—, —N+(—O−)— or —C(H)—;
• M and Q, which may be the same or different, are —N—, —N+(—O−)— or —C(R4)—;
• wherein ring A contains 1 or 2 nitrogen atoms, and wherein when L, U, M or 0 is —N+(—O−)—, ring A contains no other nitrogen atom;
• R1 and R2, which may be the same or different, are hydrogen, C1-6alkyl, (CH2)m(C3-6cycloalkyl) wherein m=0, 1, 2 or 3, or R1 and R2 together with the nitrogen to which they are attached form an azetidine ring;
• W, Y and Z, which may be the same or different, are hydrogen, halogen, C1-6alkyl, CF3, OCF3, C1-4alkylthio or C1-4alkoxy;
• or Y and Z are linked so that, together with the interconnecting atoms, Y and Z form a fused 5 to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic, and wherein when Y and Z form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen;
• and wherein W, Y and Z are not all hydrogen;
• and
• each R4 is independently:
• A-X, wherein A=—(CH2)p— where p is 0, 1 or 2;
• X is hydrogen, CONR6R7, SO2NR6R7, SO2NHC(═O)R6, hydroxy, C1-4alkoxy, NR8SO2R9, NO2, NR6R11, CN, CO2R10, SR10, S(O)R9 or SO2R10;
• R6, R7, R8 and R10 which may be the same or different, are hydrogen or C1-6alkyl optionally substituted independently by one or more R12;
• R9 is C1-6 alkyl optionally substituted independently by one or more R12;
• R11 is hydrogen, C1-6 alkyl optionally substituted independently by one or more R12, C(O)R6, CO2R9, C(O)NHR6 or SO2NR6R7;
• R12 is fluoro, hydroxy, CO2H, C3-6cycloalkyl, NH2, CONH2, C1-6alkoxy, C1-6alkoxycarbonyl or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally substituted independently by one or more R13;
• or R6 and R7, together with the nitrogen to which they are attached, form a 4-, 5- or 6-membered heterocyclic ring optionally substituted independently by one or more R13;
• or
• a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R13;
• wherein R13 is hydroxy, C1-C4alkoxy, fluoro, C1-C6alkyl, haloalkyl,
• haloalkoxy, —NH2, —NH(C1-C6alkyl) or —N(C1-C6alkyl)2;
• or when both M and Q are CR4, the R4 groups are linked so that together with the interconnecting atoms, the R4 groups form a fused 5- to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic.