Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
OwnerLinda Arterburn, James Hoffman +2inventors
InventorsLinda Arterburn, James Hoffman, Harry Oken, Mary Van Elswyk
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Abstract
This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients. Methods of the invention comprise administration of DHA alone and in combination with antiplatelet drugs.
Claims21
A method for impeding the development or progression of a disease associated with subclinical inflammation comprising administering docosahexaenoic acid (DHA) to a patient in an amount effective to reduce subclinical inflammation.
A method of prophylactic therapy for subclinical inflammation comprising administering DHA to a patient having an elevated level of circulating CRP, wherein said DHA is administered in an amount sufficient to reduce circulating CRP in the patient.
The method of any preceding claim wherein the patient exhibits at least three symptoms selected from abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure and fasting glucose greater than 100 mg/dL.
A method of treating an individual at risk of having a stroke comprising:
- a) assessing an individual to determine if three or more risk factors are present wherein the risk factors are selected from abdominal obesity (men>40″ waist, women >35″), high triglycerides (≧150 mg/dL), low HDL cholesterol (men<40 mg/dL women<50 mg/dL), high blood pressure (≧130/24 85), small LDL particle size and high fasting glucose (>110 mg/dL) in combination with elevated levels of C-reactive protein;
- b) providing said individual with a dosage of DHA which is greater than about 750 mg/day for a period of more than three months.
The method of any preceding claim wherein said administration of DHA is chronic.
The method of any preceding claim wherein DHA makes up at least about 70% of the fatty acids administered as a triglyceride oil, free fatty acids, fatty acid alkyl esters or combinations thereof.
The method of any preceding claim wherein DHA is administered in a triglyceride oil which contains no other ω-3 PUFA greater than about 4% of total fatty acid.
The method of any preceding claim wherein DHA is administered in a triglyceride oil which has an EPA content less than about one-fifth that of DHA.
The method of any preceding claim wherein DHA is administered in a food product that contains DHA as a triglyceride oil, free fatty acids, fatty acid alkyl esters or combinations thereof.
Dependencies are inferred from the claim text.