2-Alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
AssigneeAkzo Nobel N.V.
InventorsMinggiang Zhang, Gary Tarver
Life of this patent
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Abstract
Disclosed is a 2-alkylated-cyclodextrin derivative having the general formula I wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (CH2)p-phenylene-(CH2)q, (C1-6)alkylene, or (CH2)r—S—(C1-4)alkylene, of which each alkylene group may be substituted with 1-3 OH groups; p and r are independently 1-4; q is 0-4; X is COOH, SO2OH, (CH2—CH2—O)s—H or OH; s is 1-3; or a pharmaceutically acceptable salt thereof. The 2-alkylated-cyclodextrin derivatives are suitable for use in the reversal of drug-induced neuromuscular block.
Claims9
A 2-alkylated-cyclodextrin derivative having the general formula I
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- wherein m is 0-7 and n is 1-8 and m+n=7 or 8;
- R is (CH2)p-phenylene-(CH2)q, (C1-6)alkylene, or (CH2)r—S—(C1-4)alkylene, of which each alkylene group may be substituted with 1-3 OH groups;
- p and r are independently 1-4;
- q is 0-4;
- X is COOH, SO2OH, (CH2—CH2—O)s—H or OH;
- s is 1-3;
- or a pharmaceutically acceptable salt thereof;
- with the proviso that when m+n=7, n is 1 and X is OH, R cannot be 2-methyl-1,2-ethanediyl, 2,2-dimethyl-1,2-ethanediyl, 2-hydroxy-1,3-propanediyl or 2-hydroxy-2-methyl-1,3-propanediyl.
A pharmaceutical composition comprising a 2-alkylated-cyclodextrin derivative having the general formula I
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- wherein m is 0-7 and n is 1-8 and m+n=7 or 8;
- R is (CH2)p-phenylene-(CH2)q, (C1-6)alkylene, or (CH2)r—S—(C1-4)alkylene, of which each alkylene group may be substituted with 1-3 OH groups;
- p and r are independently 1-4;
- q is 0-4;
- X is COOH, SO2OH, (CH2—CH2—O)s—H or OH;
- s is 1-3;
- or a pharmaceutically acceptable salt thereof, in admixture with pharmaceutically acceptable auxilliaries.
Dependencies are inferred from the claim text.