Stable granulates containing s-adenosylmethionine and process for the preparation thereof
OwnerCantabene Carlo, Magri?apos; Paoloinventors
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Abstract
A fluid bed granulation process for manufacturing non-hygroscopic, stable granulates containing a water-soluble salt of S-adenosylmethionine is described. Said process comprises: a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) and b) the fluid bed granulation of the mixture. Granulates obtainable by said process and solid oral pharmaceutical forms obtainable by said granulates are disclosed.
Claims15
A process for manufacturing granulates containing a water-soluble salt of S-adenosylmethionine characterized by comprising:
- a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) and
- b) the fluid bed granulation of the mixture so obtained at a temperature not above 62° C.
Dependencies are inferred from the claim text.