Hepatitis C virus inhibitors

A compound having the formula

• 999
• wherein:
• (a) R1 is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl;
• (b) m is 1 or 2;
• (c) n is 1 or 2;
• (d) R2 is H, C1-6 alkyl, C2-6 alkenyl or C3-7 cycloalkyl, each optionally substituted with halogen;
• (e) R3 is C1-8 alkyl optionally substituted with halo, cyano, amino, C1-6 dialkylamino, C6-10 aryl, C7-14 alkylaryl, C1-6 alkoxy, carboxy, hydroxy, aryloxy, C7-14 alkylaryloxy, C2-6 alkylester, C8-15 alkylarylester;
• C3-12 alkenyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, wherein the cycloalkyl or alkylcycloalkyl are optionally substituted with hydroxy, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy;
• or R3 together with the carbon atom to which it is attached forms a C3-7 cycloalkyl group optionally substituted with C2-6 alkenyl;
• (f) Y is H, phenyl substituted with nitro, pyridyl substituted with nitro, or C1-6 alkyl optionally substituted with cyano, OH or C3-7 cycloalkyl;
• provided that if R4 or R5 is H then Y is H;
• (g) B is H, C1-6 alkyl, R4—(C═O)—, R4O(C═O)—, R4—N(R5)—C(═O)—, R4—N(R5)—C(═S)—, R4SO2—, or R4—N(R5)—SO2—;
• (h) R4 is (i) C1-10 alkyl optionally substituted with phenyl, carboxyl, C1-6 alkanoyl, 1-3 halogen, hydroxy, —OC(O)C1-6 alkyl, C1-6 alkoxy, amino optionally substituted with C1-6 alkyl, amido, or (lower alkyl) amido;
• (ii) C3-7 cycloalkyl, C3-7 cycloalkoxy, or C4-10 alkylcycloalklyl, each optionally substituted with hydroxy, carboxyl, (C1-6 alkoxy)carbonyl, amino optionally substituted with C1-6 alkyl, amido, or (lower alkyl) amido;
• (iii) C6-10 aryl or C7-16 arylalkyl, each optionally substituted with C1-6 alkyl, halogen, nitro, hydroxy, amido, (lower alkyl) amido, or amino optionally substituted with C1-6 alkyl;
• (iv) Het;
• (v) bicyclo(1.1.1)pentane;
• or (vi) —C(O)OC1-6 alkyl, C2-6alkenyl or C2-6 alkynyl;
• (i) R5 is H;
• C1-6alkyl optionally substituted with 1-3 halogens;
• or C1-6 alkoxy provided R4 is C1-10 alkyl;
• (j) X is O, S, SO, SO2, OCH2, CH2O or NH;
• (k) R′ is Het;
• or C6-10 aryl or C7-14 alkylaryl, optionally substituted with Ra;
• and
• (l) Ra is C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkoxy, C3-7 cycloalkoxy, halo-C1-6 alkyl, CF3, mono-or di-halo-C1-6 alkoxy, cyano, halo, thioalkyl, hydroxy, alkanoyl, NO2, SH, amino, C1-6alkylamino, di (C1-6) alkylamino, di (C1-6) alkylamide, carboxyl, (C1-6) carboxyester, C1-6 alkylsulfone, C1-6 alkylsulfonamide, di (C1-6) alkyl(alkoxy)amine, C6aryl, C7-14 alkylaryl, or a 5-7 membered monocyclic heterocycle;
• with the proviso that X—R′ is not
• 1000
• or a pharmaceutically acceptable salt, solvate or prodrug thereof.