US 2004/0106557 A1 · Peptide ligands for prostate specific antigen

Abstract

The present invention relates to novel peptide ligands for prostate specific antigen (PSA) binding specifically with it and enhancing its enzyme activity, to a process for preparation of these peptides, to diagnostic and pharmaceutical compositions comprising these peptides, to the use of these peptides for pharmaceutical and research preparations, to methods using these peptides in diagnostic assays for determination of the concentrations of various molecular forms of PSA, to methods for modulating the PSA enzyme activity and PSA activity dependent conditions by using these peptides either in vivo or in vitro and to the use of these peptides in procedures for biochemical isolation and purification of PSA.

Claims37

Dependent claims

Binding agent for prostate specific antigen, comprising

a. a peptide having at least 6 amino acids bonded together to form a peptide backbone and including at least one pair of cysteines which are spaced apart by a number of at least two amino acids and interconnected by a disulfide bond to form a cyclic structure defined by the cysteines, the intermediary amino acids and the disulfide bond;
or
b. a peptidomimetic compound having a spatial conformation similar to the peptide, said peptide or peptidomimetic compound exhibiting selective binding to free prostate specific antigen.

Dependencies are inferred from the claim text.

Peptide ligands for prostate specific antigen

Life of this patent

Peptide ligands for prostate specific antigen

Life of this patent

Abstract

Claims37