Remedies for arthritis deformans and remedies for rheumatoid arthritis
OwnerRei Imaizumiinventor
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Abstract
The present invention aims at providing a therapeutic agent effective for diseases of osteoarthritis and chronic rheumatoid arthritis, and provides a therapeutic agent for osteoarthritis or therapeutic agent for chronic rheumatoid arthritis which contains, as an active ingredient, a chondromodulin-I protein having an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor and an activity of suppressing hyper degradation of cartilage matrix.
Claims36
A therapeutic agent for osteoarthritis containing a chondromodulin-I protein having activities of the following (i) and (ii) as an active ingredient:
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for osteoarthritis, which contains a protein defined in the following (a) or (b) as an active ingredient:
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for osteoarthritis, which contains DNA coding for a protein defined in the following (a) or (b):
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for chronic rheumatoid arthritis, which contains a chondromodulin-I protein having activities of the following (i) and (ii) as an active ingredient:
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for chronic rheumatoid arthritis, which contains a protein defined in the following (a) or (b) as an active ingredient:
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for chronic rheumatoid arthritis, which contains DNA coding for a protein defined in the following (a) or (b):
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
An articular chondrocyte growth agent, which contains a chondromodulin-I protein having activities of the following (i) and (ii) as an active ingredient:
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
An articular chondrocyte growth agent, which contains a protein defined in the following (a) or (b) as an active ingredient:
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
An articular chondrocyte growth agent, which contains DNA coding for a protein defined in the following (a) or (b)
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
An agent for suppressing hyper degradation of cartilage matrix, which contains a chondromodulin-I protein having activities of the following (i) and (ii) as an active ingredient:
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
An agent for suppressing hyper degradation of cartilage matrix, which contains a protein defined in the following (a) or (b) as an active ingredient:
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
An agent for suppressing hyper degradation of cartilage matrix, which contains DNA coding for a protein defined in the following (a) or (b):
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for a disease caused by suppression of growth of articular chondrocytes, which contains a chondromodulin-I protein having activities of the following (i) and (ii) as an active ingredient:
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for a disease caused by suppression of growth of articular chondrocytes, which contains a protein defined in the following (a) or (b) as an active ingredient:
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for a disease caused by suppression of growth of articular chondrocytes, which contains DNA coding for a protein defined in the following (a) or (b)
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for a disease caused by hyper degradation of cartilage matrix, which contains a chondromodulin-I protein having activities of the following (i) and (ii) as an active ingredient:
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for a disease caused by hyper degradation of cartilage matrix, which contains a protein defined in the following (a) or (b) as an active ingredient:
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
A therapeutic agent for a disease caused by hyper degradation of cartilage matrix, which contains DNA coding for a protein defined in the following (a) or (b):
- (a) a protein which has the amino acid sequence of SEQ ID NO:
- 2, 4 or 6;
- (b) a protein which has an amino acid sequence of SEQ ID NO:
- 2, 4 or 6 including deletion, substitution, insertion or addition of one or several amino acids, and has activities of the following (i) and (ii):
- (i) an activity of growing articular chondrocytes by itself or under coexistence of a basic fibroblast growth factor;
- (ii) an activity of suppressing hyper degradation of cartilage matrix.
Dependencies are inferred from the claim text.