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US 2004/0106545 A1Published application
Compounds and methods for modulating cell adhesion
AssigneeAdherex Technologies, Inc.
InventorsOrest W. Blaschuk, Barbara J. Gour, Riaz Farookhi, Anmar Ali
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Abstract
Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
Claims54
A cyclic peptide having the formula:
- 10
- wherein Z1 and Z2 are independently selected from the group consisting of amino acid residues and combinations thereof in which the residues are linked by peptide bonds;
- wherein Z1 and Z2 independently range in size from 1 to 10 residues;
- and wherein X and Y are independently selected from the group consisting of amino acid residues, wherein a disulfide bond is formed between residues X and Y.
1 more element
A cyclic peptide comprising a dimer or multimer of the sequence His-Ala-Val.
Dependencies are inferred from the claim text.