Perfluoro sulfonyl halides and related species as polymer support modifiers
AssigneeGe Healthcare Limited
InventorsChristopher Holmes, Yijun Pan
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Abstract
Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic sync) thesis are also provided.
Claims54
A support-bound activator having the formula:
- 128
- wherein
- L is a linking group component;
- X is a member selected from the group consisting of F, Cl, OH, and trisubstituted silyloxy;
- wherein the support-bound activator is covalently attached to a solid or semi-solid support.
An activated support comprising a solid or semi-solid support;
- and at least one support-bound activator having the formula:
- 130
- wherein
- L is a linking group component;
- X is a member selected from the group consisting of F, Cl, OH, and trisubstituted silyloxy;
- and
- wherein the support-bound activator is covalently attached to the solid or semi-solid support.
A support-activated target comprising a solid or semi-solid support;
- an activating group covalently attached to the solid or semi-solid support, wherein the activating group has the formula:
- 132
- and wherein L is a linking group component;
- and a target group covalently attached to the activating group;
- wherein the target group can be cleaved from the activating group by a nucleophile.
A library of support-activated targets comprising a plurality of support-activated target members, wherein each support-activated target member further comprises a solid or semi-solid support;
- an activating group covalently attached to the solid or semi-solid support, wherein the activating group has the formula:
- 134
- wherein L is an linking group component;
- and a target group covalently attached to the activating group;
- wherein the target group of at least one support-activated target member in the library is different from the target group of at least one other support-activated target member in the library.
A strongly acidic support comprising a solid or semi-solid support;
- and at least one support-bound strongly acidic group having the formula:
- 136
- wherein
- L is a linking group component;
- and
- X is OH;
- wherein the support-bound strongly acidic group is covalently attached to the solid or semi-solid support.
A silylating support comprising a solid or semi-solid support;
- and at least one support-bound silylating group having the formula:
- 138
- wherein
- L is a linking group component;
- and
- X is a trisubstituted silyloxy;
- wherein the support-bound silylating group is covalently attached to the solid or semi-solid support.
A linker reagent having the formula:
- 140
- wherein
- L is a linking group component;
- and
- A is an attaching group.
Dependencies are inferred from the claim text.