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OwnerAnish Sen Majumdar, Iris A. Ferber +2inventors
InventorsAnish Sen Majumdar, Iris A. Ferber, Maria Frolkis, Zhuo Wang
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It has been discovered that a robust and therapeutic anti-cancer response can be generated by immunizing with a xenogeneic form of the enzyme telomerase reverse transcriptase (TERT). Cancer subjects are multiply immunized with TERT from another species—either in protein form, or with a TERT expression vector. Presence of the xenogeneic components apparently overcomes natural immunotolerance to self-antigen. The response can be focused by simultaneous or subsequent immunization with isogenic TERT. As a result, the immune system generates T lymphocytes that are cytotoxic for virtually any cancer cell, by virtue of TERT expressed due to malignant transformation. The anti-tumor response causes a substantial inhibition of tumor cell growth, demonstrating the therapeutic benefit of this invention.
A method for eliciting an immune response in a mammalian subject that is specific for its own telomerase reverse transcriptase (TERT), comprising administering to the subject an immunogenic composition containing a protein with at least 20 consecutive amino acids of TERT of another mammalian species, or a nucleic acid encoding said protein.
An immunogenic composition formulated for human administration, comprising a protein containing at least 20 consecutive amino acids of telomerase reverse transcriptase (TERT) of a non-human mammal, or a nucleic acid encoding said protein, which upon administration to a human patient having a tumor (optionally with simultaneous or sequential administration of another TERT protein or TERT-encoding nucleic acid) elicits an immunological response against human TERT.
A combination of pharmaceutical compositions formulated for human administration, comprising:
Dependencies are inferred from the claim text.