Production process of l-phenylanine derivatives by microorganisms
OwnerHirobumi Aokiinventor
Life of this patent
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Abstract
[Problems to be Solved]To provide a novel process for simply and easily obtaining a phenylalanine derivative having a high optical purity starting from a cinnamic acid derivative having a substituent on the phenyl group; and a microorganism applied to this process. [Means to Solve the Problems] A process for producing an L-phenylalanine derivative, characterized in that a microorganism belonging to the genus Cladosporium, an ingredient containing the microorganism or a material treated with the microorganism is allowed to act in the presence of a cinnamic acid derivative and ammonia.
Claims22
A process for producing an L-phenylalanine derivative having a substituent, represented by the following general formula (1):
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- (wherein R1, R2, R3, R4 and R5, each independently represents hydrogen, a hydroxy group, an alkyl group (a linear or branched alkyl group having from 1 to 4 carbon atoms), an alkoxy group (the alkyl group constituting the alkoxy group is a linear or branched alkyl group having from 1 to 4 carbon atoms), a cyano group, a nitro group, a halogen, NR6R7 (wherein R6 and R7 each independently represents hydrogen or a linear or branched alkyl group having from 1 to 4 carbon atoms, or R6 and R7 may form a ring having from 3 to 5 carbon atoms and this ring may contain a hetero atom), or a phenyl group which may have a substituent, provided that R1, R2, R3, R4 and R5 are not hydrogen at the same time), said process comprising utilizing the activity of a microorganism belonging to any one of the genus Cladosporium, the genus Eurotium, the genus Thanatephorus, the genus Gonatobotryum and the genus Sporobolomyces, an ingredient containing said microorganism or a material treated with said microorganism.
A process for producing an L-phenylalanine derivative having a substituent, represented by formula (1), comprising utilizing the activity of a microorganism belonging to any one of the genus Cladosporium, the genus Eurotium, the genus Thanatephorus, the genus Gonatobotryum and the genus Sporobolomyces, an ingredient containing said microorganism or a material treated with said microorganism in the presence of ammonia and a cinnamic acid derivative represented by the following formula (2):
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- (wherein R1, R2, R3, R4 and R5 each independently represents hydrogen, a hydroxyl group, an alkyl group (a linear or branched alkyl group having from 1 to 4 carbon atoms), an alkoxy group (the alkyl group constituting the alkoxy group is a linear or branched alkyl group having from 1 to 4 carbon atoms), a cyano group, a nitro group, a halogen, NR6R7 (wherein R6 and R7 each independently represents hydrogen or a linear or branched alkyl group having from 1 to 4 carbon atoms or R6 and R7 may form a ring having from 3 to 5 carbon atoms and this ring may contain a hetero atom) or a phenyl group which may have a substituent, provided that R1, R2, R3, R4 and R5 are not necessarily hydrogen at the same time).
Dependencies are inferred from the claim text.