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AssigneeRush University Medical Center
InventorsAzra Raza, Harvey Preisler
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The present invention relates first, to the identification of a novel retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of MDS and MDS associated disorders. The present invention further relates to methods for using the MDS associated retroviral nucleotides for the detection of MDS and MDS associated disorders in patient samples. The present invention also relates to methods for using and targeting the MDS associated retroviral POL nucleotides in gene therapy protocols for the treatment of MDS and MDS associated disorders in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of MDS and MDS associated disorders in tissue samples.
A method for identifying the presence of a myelodysplastic syndrome associated virus in a biological sample comprising detecting the presence or absence of a myelodysplastic syndrome associated virus in a biological sample.
A human myelodysplastic syndrome associated virus isolated from ATCC Deposit No. PTA-2733 or PTA-2734.
An isolated myelodysplastic syndrome associated retrovirus comprised of a viral particle size ranging from 40 to 60 nm and a density of 1.14 to 1.16 as measured by a sugar density gradient with the proviso that the virus is not HIV, HTLV or MMTV.
A method for isolating myelodysplastic syndrome associated virus comprising:
Dependencies are inferred from the claim text.