Analysis of pharmaceutical solubility and stability
AssigneeTransform Pharmaceuticals, Inc.
InventorsHongming Chen, Hector Guzman, Colin Gardner
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Abstract
Methods and systems are disclosed that can be used for the automated preparation and analysis of mixtures comprising a compound-of-interest (e.g., the active ingredient of a pharmaceutical composition) and one or more excipients. Specific embodiments of the invention are particularly suited for the precise preparation and screening of small amounts of excipients, compounds-of-interest, and mixtures thereof. The invention is also well suited for the preparation and screening of small amounts of mixtures comprising high concentrations of compounds-of-interest.
Claims18
A method of screening compositions that comprise a compound-of-interest, which comprises:
- (a) preparing an array of substantially non-aqueous samples, wherein each sample in the array comprises a controlled amount of the compound-of-interest and a liquid excipient, and wherein at least two of the samples differ with respect to the liquid excipient they contain and/or the concentration of the compound-of-interest, and further wherein each sample has a concentration greater than about 1 mg/mL and a viscosity greater than about 100 centipoise;
- (b) using a positive displacement pump to dispense less than 250 microliters of an excipient with a viscosity of at least 100 centipoise;
- (c) identifying samples in the array wherein at least some of the compound-of-interest dissolved in the liquid excipient;
- and
- (d) ranking the identified samples.
Dependencies are inferred from the claim text.