Acidified nitrite as an antimicrobial agent
AssigneeAberdeen University, a Great Britain corporation
InventorsNigel Benjamin, Hamish Dougall, Anthony Ormerod
Life of this patent
Estimating the term…
Abstract
The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions. The invention also provides delivery systems for the topical medicament.
Claims18
A dosage form for the treatment of bacterial, viral or fungal conditions which comprises,
- a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and
- a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor;
- wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions.
A dosage form adapted for the treatment of a virus mediated condition by topical application of a medicament to or adjacent to an environment of use, comprising an admixture of nitrogen oxides generated at the environment of use from a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH or the environment of use to below pH, and a pharmaceutically acceptable source of nitrogen oxides or a nitrate precursor therefor.
A delivery system for the topical application of a medicament for the in vivo treatment of the epidermis, comprising an adhesive layer and a support layer impregnated with at least one of the components of the medicament characterized in that the components of the medicament comprise separately a pharmaceutically acceptable acidifying agent and a pharmaceutically acceptable source of nitrogen oxides or a precursor therefor, and a means for combining the pharmaceutically acceptable acidifying agent with the source of nitrogen oxides at the environment of use.
A two-part delivery system for topical application of a medicament for the in vivo treatment of a viral, bacterial or fungal infection of the epidermis, said system comprising separately;
- (a) a first waxy component comprising a pharmaceutically acceptable acidifying agent;
- and
- (b) a second waxy component comprising a pharmaceutically acceptable source of nitrogen oxides, whereby when topically applied simultaneously or immediately sequentially to an environment of use, active nitrogen oxides are released thereto.
Dependencies are inferred from the claim text.