Metal compunds, mixed or sulphated, as phosphate binders
AssigneeCrosfield Limited
InventorsNorman B. Roberts, Maurice Webb, Benjamin J. Rankin
Life of this patent
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Abstract
A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30% by weight of the total phosphate present, over a pH range from 2-8.
Claims15
A mixed metal compound for pharmaceutical use which is free from aluminium and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8.
A mixed metal compound according to any preceding claim, wherein the metals are iron(III) and at least one of magnesium, calcium, lanthanum and cerium.
A mixed metal compound according to any preceding claim, which contains at least one of hydroxyl and carbonate anions.
Use, in a method of preparing a medicament for treatment of hyperphosphataemia, of a mixed metal compound according to any preceding claim.
Use, in a method of preparing a medicament for treatment of hyperphosphataemia, of a metal sulphate material selected from at least one of calcium, lanthanum and cerium sulphate compounds treated with an alkali solution.
A metal sulphate material for pharmaceutical use selected from at least one of calcium, lanthanum and cerium sulphate compounds treated with an aqueous solution of an alkaline hydroxide, which said material comprises a solid material.
A metal sulphate material for pharmaceutical use, which metal sulphate material comprises a solid material selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8.
A method of preparing a metal sulphate material, which method comprises treating a metal sulphate comprising a solid material selected from at least one of calcium, lanthanum and cerium sulphate with an alkali solution.
Dependencies are inferred from the claim text.