Pneumococcal and meningococcal vaccines formulated with interleukin-12
AssigneeWyeth Holdings Corporation
InventorsVincent J. LaPosta, John H. Eldridge
Life of this patent
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Abstract
This invention pertains to vaccine compositions comprising a mixture of antigen, such as pneumococcal or meningococcal antigen, and interleukin IL-12, which may be adsorbed onto a mineral in suspension. The pneumococcal or meningococcal antigen may be conjugated to a carrier molecule. These vaccine compositions modulate the protective immune response to the antigen.
Claims24
A composition comprising a mixture of a meningococcal capsular polysaccharide, an adjuvant amount of interleukin-12 and an aqueous suspension of alum, and optionally comprising a physiologically acceptable vehicle.
A method of eliciting an immune response to a meningococcal capsular polysaccharide, comprising administering to a mammalian host an effective amount of a vaccine composition comprising a mixture of a meningococcal capsular polysaccharide, an adjuvant amount of interleukin-12 and an aqueous suspension of alum, and optionally comprising a physiologically acceptable vehicle.
An immunogenic composition comprising a mixture of a meningococcal capsular polysaccharide, an adjuvant amount of interleukin-12 and an aqueous suspension of alum, and optionally comprising a physiologically acceptable vehicle.
Dependencies are inferred from the claim text.